UQCRC1

Ubiquinol-cytochrome c reductase core protein I

PDB rendering based on 1be3.

Available structures
PDB	1be3, 1bgy, 1l0l, 1l0n, 1ntk, 1ntm, 1ntz, 1nu1, 1pp9, 1ppj, 1qcr, 1sqq, 1sqv, 1sqx, 2a06, 2fyu

Identifiers

Symbols

UQCRC1; D3S3191; QCR1; UQCR1

External IDs

OMIM: 191328 MGI: 107876 HomoloGene: 2525 GeneCards: UQCRC1 Gene

EC number

1.10.2.2

Gene Ontology
Molecular function	• catalytic activity • metalloendopeptidase activity • protein binding • ubiquinol-cytochrome-c reductase activity • zinc ion binding • protein complex binding • metal ion binding
Cellular component	• mitochondrion • mitochondrial inner membrane • mitochondrial respiratory chain • mitochondrial respiratory chain complex III • membrane
Biological process	• oxidative phosphorylation • mitochondrial electron transport, ubiquinol to cytochrome c • proteolysis • transport • aerobic respiration • response to activity • respiratory electron transport chain • response to alkaloid • oxidation-reduction process
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 3:
48.64 – 48.65 Mb

Chr 9:
108.84 – 108.85 Mb

PubMed search

[1]

[2]

Cytochrome b-c1 complex subunit 1, mitochondrial is a protein that in humans is encoded by the UQCRC1 gene.^[1]^[2]

Its gene product is a subunit of the respiratory chain protein Ubiquinol Cytochrome c Reductase (UQCR, Complex III or Cytochrome bc1 complex), which consists of the products of one mitochondrially encoded gene, MTCYTB (mitochondrial cytochrome b) and ten nuclear genes: UQCRC1, UQCRC2, Cytochrome c1, UQCRFS1 (Rieske protein), UQCRB, "11kDa protein", UQCRH (cyt c1 Hinge protein), Rieske Protein presequence, "cyt. c1 associated protein", and Rieske-associated protein.

References

^ Hoffman GG, Lee S, Christiano AM, Chung-Honet LC, Cheng W, Katchman S, Uitto J, Greenspan DS (Nov 1993). "Complete coding sequence, intron/exon organization, and chromosomal location of the gene for the core I protein of human ubiquinol-cytochrome c reductase". J Biol Chem 268 (28): 21113–9. PMID 8407948.
^ "Entrez Gene: UQCRC1 ubiquinol-cytochrome c reductase core protein I". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7384.

Suzuki H, Hosokawa Y, Nishikimi M, Ozawa T (1991). "Existence of common homologous elements in the transcriptional regulatory regions of human nuclear genes and mitochondrial gene for the oxidative phosphorylation system.". J. Biol. Chem. 266 (4): 2333–8. PMID 1846623.
Broger C, Nałecz MJ, Azzi A (1980). "Interaction of cytochrome c with cytochrome bc1 complex of the mitochondrial respiratory chain.". Biochim. Biophys. Acta 592 (3): 519–27. doi:10.1016/0005-2728(80)90096-1. PMID 6251869.
Islam MM, Tanaka M, Suzuki H et al. (1994). "A complete cDNA sequence for core I protein subunit of human ubiquinol-cytochrome c reductase". Biochem. Mol. Biol. Int. 33 (2): 410. PMID 7951059.
Islam MM, Tanaka M, Suzuki H et al. (1995). "A complete cDNA sequence for core I protein subunit of human ubiquinol-cytochrome c reductase". Biochem. Mol. Biol. Int. 33 (4): 815. PMID 7981668.
Islam MM, Tanaka M, Suzuki H et al. (1994). "A complete cDNA sequence for core I protein subunit of human ubiquinol-cytochrome c reductase". Biochem. Mol. Biol. Int. 32 (5): 797–805. PMID 8069229.
Hughes GJ, Frutiger S, Paquet N et al. (1994). "Human liver protein map: update 1993". Electrophoresis 14 (11): 1216–22. doi:10.1002/elps.11501401181. PMID 8313870.
Hillier LD, Lennon G, Becker M et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
Valnot I, Kassis J, Chretien D et al. (1999). "A mitochondrial cytochrome b mutation but no mutations of nuclearly encoded subunits in ubiquinol cytochrome c reductase (complex III) deficiency". Hum. Genet. 104 (6): 460–6. doi:10.1007/s004390050988. PMID 10453733.
Hu WH, Hausmann ON, Yan MS et al. (2002). "Identification and characterization of a novel Nogo-interacting mitochondrial protein (NIMP)". J. Neurochem. 81 (1): 36–45. doi:10.1046/j.1471-4159.2002.00788.x. PMID 12067236.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Aboulaich N, Vainonen JP, Strålfors P, Vener AV (2005). "Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes". Biochem. J. 383 (Pt 2): 237–48. doi:10.1042/BJ20040647. PMC 1134064. PMID 15242332. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1134064.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Wen JJ, Garg N (2005). "Oxidative modification of mitochondrial respiratory complexes in response to the stress of Trypanosoma cruzi infection". Free Radic. Biol. Med. 37 (12): 2072–81. doi:10.1016/j.freeradbiomed.2004.09.011. PMID 15544925.
Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Kulawiec M, Arnouk H, Desouki MM et al. (2007). "Proteomic analysis of mitochondria-to-nucleus retrograde response in human cancer". Cancer Biol. Ther. 5 (8): 967–75. PMID 16775426.
Ewing RM, Chu P, Elisma F et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847948.

PDB gallery

1be3: CYTOCHROME BC1 COMPLEX FROM BOVINE

1bgy: CYTOCHROME BC1 COMPLEX FROM BOVINE

1l0l: structure of bovine mitochondrial cytochrome bc1 complex with a bound fungicide famoxadone

1l0n: native structure of bovine mitochondrial cytochrome bc1 complex

1ntk: Crystal Structure of Mitochondrial Cytochrome bc1 in Complex with Antimycin A1

1ntm: Crystal Structure of Mitochondrial Cytochrome bc1 Complex at 2.4 Angstrom

1ntz: Crystal Structure of Mitochondrial Cytochrome bc1 Complex Bound with Ubiquinone

1nu1: Crystal Structure of Mitochondrial Cytochrome bc1 Complexed with 2-nonyl-4-hydroxyquinoline N-oxide (NQNO)

1pp9: Bovine cytochrome bc1 complex with stigmatellin bound

1ppj: Bovine cytochrome bc1 complex with stigmatellin and antimycin

1qcr: CRYSTAL STRUCTURE OF BOVINE MITOCHONDRIAL CYTOCHROME BC1 COMPLEX, ALPHA CARBON ATOMS ONLY

1sqq: Crystal Structure Analysis of Bovine Bc1 with Methoxy Acrylate Stilbene (MOAS)

1sqv: Crystal Structure Analysis of Bovine Bc1 with UHDBT

1sqx: Crystal Structure Analysis of Bovine Bc1 with Stigmatellin A

2a06: Bovine cytochrome bc1 complex with stigmatellin bound

2fyu: Crystal structure of bovine heart mitochondrial bc1 with jg144 inhibitor

UQCRC1

References

Further reading