| Ubiquinol-cytochrome c reductase binding protein | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | UQCRB; FLJ92016; FLJ97033; QCR7; QP-C; QPC; UQBC; UQBP; UQCR6; UQPC | ||||||||||||
| External IDs | OMIM: 191330 MGI: 3646665 HomoloGene: 38164 GeneCards: UQCRB Gene | ||||||||||||
| EC number | 1.10.2.2 | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 7381 | 67530 | |||||||||||
| Ensembl | ENSG00000156467 | ENSMUSG00000021520 | |||||||||||
| UniProt | P14927 | n/a | |||||||||||
| RefSeq (mRNA) | NM_001199975.1 | NM_026219.1 | |||||||||||
| RefSeq (protein) | NP_001186904.1 | NP_080495.1 | |||||||||||
| Location (UCSC) | Chr 8: 97.24 – 97.25 Mb |
Chr 13: 67 – 67.01 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Ubiquinol-cytochrome c reductase binding protein, also known as UQCRB, is a protein which in humans is encoded by the UQCRB gene.[1]
The ubiquinone-binding protein is a nucleus-encoded component of ubiquinol-cytochrome c oxidoreductase (Complex III; EC 1.10.2.2) in the mitochondrial respiratory chain and plays an important role in electron transfer as a complex of ubiquinone and QP-C. Complex III consists of 10 nuclear-encoded subunits and 1 mitochondrial-encoded subunit.[1]
UQCRB is a subunit of the respiratory chain protein Ubiquinol Cytochrome c Reductase (UQCR, Complex III or Cytochrome bc1 complex), which consists of the products of one mitochondrially encoded gene:
and ten nuclear genes:
After processing the cleaved leader sequence of the iron-sulfur protein is retained as subunit 9, giving 11 subunits from 10 genes.
The bovine gene product (subunit 6) was sequenced under the name "ubiquinone-binding protein", however there is little or no evidence for a role in ubiquinone binding. Subunit 7 was identified as a Q-binding protein by photo-labeling with a ubiquinone analog (subsequent structures show it to be exposed to the lipid phase but not involved in either Q-binding site). Subunits 6 and 7 reverse position on going from Laemli gels to Weber&Osborne gels, and one might suspect the name "Q-binding protein" arose from confusion with subunit 7. I have been told however that this is not the case, and both proteins were separately identified as Q-binding proteins. Genome anotators improved the situation by naming its gene "UQCR binding", UQCRB.