UBR5
E3 ubiquitin-protein ligase UBR5 is an enzyme that in humans is encoded by the UBR5 gene.[1][2][3]
This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation.[3]
Interactions
UBR5 has been shown to interact with TOPBP1,[4] CIB1,[5] MAPK1[6] and Karyopherin alpha 1.[5]
References
- ^ Callaghan MJ, Russell AJ, Woollatt E, Sutherland GR, Sutherland RL, Watts CK (Mar 1999). "Identification of a human HECT family protein with homology to the Drosophila tumor suppressor gene hyperplastic discs". Oncogene 17 (26): 3479–91. doi:10.1038/sj.onc.1202249. PMID 10030672.
- ^ Tasaki T, Mulder LC, Iwamatsu A, Lee MJ, Davydov IV, Varshavsky A, Muesing M, Kwon YT (Aug 2005). "A Family of Mammalian E3 Ubiquitin Ligases That Contain the UBR Box Motif and Recognize N-Degrons". Mol Cell Biol 25 (16): 7120–36. doi:10.1128/MCB.25.16.7120-7136.2005. PMC 1190250. PMID 16055722. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1190250.
- ^ a b "Entrez Gene: EDD1 E3 ubiquitin protein ligase, HECT domain containing, 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51366.
- ^ Honda, Yoshiomi; Tojo Masahide, Matsuzaki Kazuhito, Anan Tadashi, Matsumoto Mitsuhiro, Ando Masayuki, Saya Hideyuki, Nakao Mitsuyoshi (Feb. 2002). "Cooperation of HECT-domain ubiquitin ligase hHYD and DNA topoisomerase II-binding protein for DNA damage response". J. Biol. Chem. (United States) 277 (5): 3599–605. doi:10.1074/jbc.M104347200. ISSN 0021-9258. PMID 11714696.
- ^ a b Henderson, Michelle J; Russell Amanda J, Hird Samantha, Muñoz Marcia, Clancy Jennifer L, Lehrbach Gillian M, Calanni Sophina T, Jans David A, Sutherland Robert L, Watts Colin K W (Jul. 2002). "EDD, the human hyperplastic discs protein, has a role in progesterone receptor coactivation and potential involvement in DNA damage response". J. Biol. Chem. (United States) 277 (29): 26468–78. doi:10.1074/jbc.M203527200. ISSN 0021-9258. PMID 12011095.
- ^ Eblen, Scott T; Kumar N Vinay, Shah Kavita, Henderson Michelle J, Watts Colin K W, Shokat Kevan M, Weber Michael J (Apr. 2003). "Identification of novel ERK2 substrates through use of an engineered kinase and ATP analogs". J. Biol. Chem. (United States) 278 (17): 14926–35. doi:10.1074/jbc.M300485200. ISSN 0021-9258. PMID 12594221.
Further reading
- Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
- Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
- Deo RC, Sonenberg N, Burley SK (2001). "X-ray structure of the human hyperplastic discs protein: An ortholog of the C-terminal domain of poly(A)-binding protein". Proc. Natl. Acad. Sci. U.S.A. 98 (8): 4414–9. doi:10.1073/pnas.071552198. PMC 31849. PMID 11287654. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=31849.
- Honda Y, Tojo M, Matsuzaki K, et al. (2002). "Cooperation of HECT-domain ubiquitin ligase hHYD and DNA topoisomerase II-binding protein for DNA damage response". J. Biol. Chem. 277 (5): 3599–605. doi:10.1074/jbc.M104347200. PMID 11714696.
- Henderson MJ, Russell AJ, Hird S, et al. (2002). "EDD, the human hyperplastic discs protein, has a role in progesterone receptor coactivation and potential involvement in DNA damage response". J. Biol. Chem. 277 (29): 26468–78. doi:10.1074/jbc.M203527200. PMID 12011095.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Eblen ST, Kumar NV, Shah K, et al. (2003). "Identification of novel ERK2 substrates through use of an engineered kinase and ATP analogs". J. Biol. Chem. 278 (17): 14926–35. doi:10.1074/jbc.M300485200. PMID 12594221.
- Zhang C, Dowd DR, Staal A, et al. (2003). "Nuclear coactivator-62 kDa/Ski-interacting protein is a nuclear matrix-associated coactivator that may couple vitamin D receptor-mediated transcription and RNA splicing". J. Biol. Chem. 278 (37): 35325–36. doi:10.1074/jbc.M305191200. PMID 12840015.
- Clancy JL, Henderson MJ, Russell AJ, et al. (2003). "EDD, the human orthologue of the hyperplastic discs tumour suppressor gene, is amplified and overexpressed in cancer". Oncogene 22 (32): 5070–81. doi:10.1038/sj.onc.1206775. PMID 12902990.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Colland F, Jacq X, Trouplin V, et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=442148.
- Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
- Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells". J. Proteome Res. 4 (4): 1339–46. doi:10.1021/pr050048h. PMID 16083285.
- Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1459365.
- Henderson MJ, Munoz MA, Saunders DN, et al. (2007). "EDD mediates DNA damage-induced activation of CHK2". J. Biol. Chem. 281 (52): 39990–40000. doi:10.1074/jbc.M602818200. PMID 17074762.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847948.
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PDB gallery
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1i2t: X-RAY STRUCTURE OF THE HUMAN HYPERPLASTIC DISCS PROTEIN: AN ORTHOLOG OF THE C-TERMINAL DOMAIN OF POLY(A)-BINDING PROTEIN
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External links