UBE2H

Ubiquitin-conjugating enzyme E2H

PDB rendering based on 1yh6.

Available structures
PDB	1yh6

Identifiers

Symbols

UBE2H; E2-20K; UBC8; UBCH; UBCH2

External IDs

OMIM: 601082 MGI: 104632 HomoloGene: 103894 GeneCards: UBE2H Gene

EC number

6.3.2.19

Gene Ontology
Molecular function	• nucleotide binding • ubiquitin-protein ligase activity • ATP binding • ligase activity • acid-amino acid ligase activity
Biological process	• ubiquitin-dependent protein catabolic process • protein ubiquitination • protein K48-linked ubiquitination • protein K11-linked ubiquitination
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 7:
129.47 – 129.59 Mb

Chr 6:
30.16 – 30.25 Mb

PubMed search

[1]

[2]

Ubiquitin-conjugating enzyme E2 H is a protein that in humans is encoded by the UBE2H gene.^[1]^[2]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein sequence is 100% identical to the mouse homolog and 98% identical to the frog and zebrafish homologs. Two alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms.^[2]

References

^ Kaiser P, Seufert W, Hofferer L, Kofler B, Sachsenmaier C, Herzog H, Jentsch S, Schweiger M, Schneider R (Apr 1994). "A human ubiquitin-conjugating enzyme homologous to yeast UBC8". J Biol Chem 269 (12): 8797–802. PMID 8132613.
^ ^a ^b "Entrez Gene: UBE2H ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7328.

Wefes I, Mastrandrea LD, Haldeman M, et al. (1995). "Induction of ubiquitin-conjugating enzymes during terminal erythroid differentiation.". Proc. Natl. Acad. Sci. U.S.A. 92 (11): 4982–6. doi:10.1073/pnas.92.11.4982. PMC 41831. PMID 7761435. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=41831.
Kaiser P, Mandl S, Schweiger M, Schneider R (1996). "Characterization of functionally independent domains in the human ubiquitin conjugating enzyme UbcH2.". FEBS Lett. 377 (2): 193–6. doi:10.1016/0014-5793(95)01323-7. PMID 8543049.
Hayashida S, Yamasaki K, Asada Y, et al. (2000). "Construction of a physical and transcript map flanking the imprinted MEST/PEG1 region at 7q32.". Genomics 66 (2): 221–5. doi:10.1006/geno.2000.6206. PMID 10860668.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2882961.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
Vourc'h P, Martin I, Bonnet-Brilhault F, et al. (2005). "Mutation screening and association study of the UBE2H gene on chromosome 7q32 in autistic disorder.". Psychiatr. Genet. 13 (4): 221–5. doi:10.1097/01.ypg.0000084946.07075.37. PMID 14639049.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Bartee E, Mansouri M, Hovey Nerenberg BT, et al. (2004). "Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins.". J. Virol. 78 (3): 1109–20. doi:10.1128/JVI.78.3.1109-1120.2004. PMC 321412. PMID 14722266. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=321412.
Chuang TH, Ulevitch RJ (2004). "Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors.". Nat. Immunol. 5 (5): 495–502. doi:10.1038/ni1066. PMID 15107846.
Kim HJ, Chong KH, Kang SW, et al. (2005). "Identification of cyclophilin A as a CD99-binding protein by yeast two-hybrid screening.". Immunol. Lett. 95 (2): 155–9. doi:10.1016/j.imlet.2004.07.001. PMID 15388255.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

PDB gallery

1yh6:

Posttranslational modification

Chaperones/
protein folding

Heat shock proteins/ Chaperonins	Hsp10/GroES (Early pregnancy factor) · Hsp27 · Hsp47 · HSP60/GroEL Hsp40/DnaJ (A1, A2, A3, B1, B2, B11, B4, B6, B9, C1, C3, C5, C6, C7, C10, C11, C13, C14, C19) Hsp70 (1A, 1B, 1L, 2, 4, 4L, 5, 6, 7, 8, 9, 12A, 14) Hsp90 (α₁, α₂, β, ER, TRAP1)

Other	Alpha crystallin · Clusterin · Survival of motor neuron (SMN1, SMN2)

Protein targeting

Signal peptide

Ubiquitin

E1 Ubiquitin-activating enzyme (UBA1, UBA2, UBA3, UBA5, UBA6, UBA7, ATG7, NAE1, SAE1)

E2 Ubiquitin-conjugating enzyme (A • B • C • D1, D2, D3 • E1, E2, E3 • G1, G2 • H • I • J1, J2 • K • L1, L2, L3, L4, L6 • M • N • O • Q1, Q2 • R1 (CDC34), R2 • S • V1, V2 • Z)

E3 Ubiquitin ligase (VHL, Cullin, CBL, MDM2, FANCL, UBR1)

Deubiquitinating enzyme: Ataxin 3 • USP6 • CYLD

ATG3 • BIRC6 • UFC1

Other

SUMO protein

see also posttranslational modification disorders
B bsyn: dna (repl, cycl, reco, repr) · tscr (fact, tcrg, nucl, rnat, rept, ptts) · tltn (risu, pttl, nexn) · dnab, rnab/runp · stru (domn, 1°, 2°, 3°, 4°)

UBE2H

References

Further reading