UBASH3A

Ubiquitin associated and SH3 domain containing A

PDB rendering based on 2crn.

Available structures
PDB	2crn

Identifiers

Symbols

UBASH3A; CLIP4; STS-2; TULA

External IDs

OMIM: 605736 MGI: 1926074 HomoloGene: 56833 GeneCards: UBASH3A Gene

Gene Ontology
Cellular component	• nucleus • cytoplasm • cytosol
Biological process	• regulation of cytokine production • negative regulation of T cell receptor signaling pathway
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

n/a

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 21:
42.7 – 42.74 Mb

Chr 17:
31.34 – 31.38 Mb

PubMed search

[1]

[2]

Ubiquitin-associated and SH3 domain-containing protein A is a protein that in humans is encoded by the UBASH3A gene.^[1]^[2]

References

^ Wattenhofer M, Shibuya K, Kudoh J, Lyle R, Michaud J, Rossier C, Kawasaki K, Asakawa S, Minoshima S, Berry A, Bonne-Tamir B, Shimizu N, Antonarakis SE, Scott HS (Apr 2001). "Isolation and characterization of the UBASH3A gene on 21q22.3 encoding a potential nuclear protein with a novel combination of domains". Hum Genet 108 (2): 140–7. doi:10.1007/s004390000453. PMID 11281453.
^ "Entrez Gene: UBASH3A ubiquitin associated and SH3 domain containing, A". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=53347.

Smirnova EV, Collingwood TS, Bisbal C, et al. (2008). "TULA proteins bind to ABCE-1, a host factor of HIV-1 assembly, and inhibit HIV-1 biogenesis in a UBA-dependent fashion.". Virology 372 (1): 10–23. doi:10.1016/j.virol.2007.10.012. PMID 18006034.
Collingwood TS, Smirnova EV, Bogush M, et al. (2007). "T-cell ubiquitin ligand affects cell death through a functional interaction with apoptosis-inducing factor, a key factor of caspase-independent apoptosis.". J. Biol. Chem. 282 (42): 30920–8. doi:10.1074/jbc.M706870200. PMID 17709377.
Bertelsen V, Breen K, Sandvig K, et al. (2007). "The Cbl-interacting protein TULA inhibits dynamin-dependent endocytosis.". Exp. Cell Res. 313 (8): 1696–709. doi:10.1016/j.yexcr.2007.02.017. PMID 17382318.
Hu YH, Warnatz HJ, Vanhecke D, et al. (2006). "Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins.". BMC Genomics 7: 155. doi:10.1186/1471-2164-7-155. PMC 1526728. PMID 16780588. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1526728.
Hoeller D, Crosetto N, Blagoev B, et al. (2006). "Regulation of ubiquitin-binding proteins by monoubiquitination.". Nat. Cell Biol. 8 (2): 163–9. doi:10.1038/ncb1354. PMID 16429130.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Kowanetz K, Crosetto N, Haglund K, et al. (2004). "Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases.". J. Biol. Chem. 279 (31): 32786–95. doi:10.1074/jbc.M403759200. PMID 15159412.
Feshchenko EA, Smirnova EV, Swaminathan G, et al. (2004). "TULA: an SH3- and UBA-containing protein that binds to c-Cbl and ubiquitin.". Oncogene 23 (27): 4690–706. doi:10.1038/sj.onc.1207627. PMID 15107835.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.

PDB gallery

2crn: Solution structure of the UBA domain of human UBASH3A protein

UBASH3A

References

Further reading