| Systematic (IUPAC) name | |
|---|---|
| (2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-indol-3-yl)propanoic acid | |
| Clinical data | |
| Pregnancy cat. | ? |
| Legal status | Non-regulated |
| Identifiers | |
| ATC code | None |
| PubChem | CID 9961318 |
| Chemical data | |
| Formula | C35H46N6O7 |
| Mol. mass | 662.8 g/mol |
| SMILES | eMolecules & PubChem |
Tynorphin is a synthetic opioid peptide which is a potent and competitive inhibitor of the enkephalinase class of enzymes which break down the endogenous enkephalin peptides.[1] It specifically inactivates dipeptidyl aminopeptidase III (DPP3) with very high efficacy, but also inhibits neutral endopeptidase (NEP), aminopeptidase N (APN), and angiotensin-converting enzyme (ACE) to a lesser extent.[1] It has a pentapeptide structure with the amino acid sequence Val-Val-Tyr-Pro-Trp (VVYPW).
Tynorphin was discovered in an attempt to develop an enkephalinase inhibitor of greater potency than spinorphin.[1]