Tuftelin

Tuftelin 1
Identifiers
Symbols TUFT1;
External IDs OMIM600087 MGI109572 HomoloGene7985 GeneCards: TUFT1 Gene
Orthologs
Species Human Mouse
Entrez 7286 22156
Ensembl ENSG00000143367 ENSMUSG00000005968
UniProt Q9NNX1 Q3TAP8
RefSeq (mRNA) NM_001126337.1 NM_011656.2
RefSeq (protein) NP_001119809.1 NP_035786.1
Location (UCSC) Chr 1:
151.51 – 151.56 Mb
Chr 3:
94.42 – 94.46 Mb
PubMed search [1] [2]

Tuftelin is an acidic phosphorylated glycoprotein found in tooth enamel. In humans, the Tuftelin protein is encoded by the TUFT1 gene.[1][2]

Contents

Function

This protein is formed for a short time during amelogenesis. The function of tuftelins is under contention, but it is proposed that it acts to start the mineralization process of enamel during tooth development.[3][4]

Other significant proteins in enamel are amelogenins, enamelins, and ameloblastins.

Research

The human encoding gene for tuftelin (TUFT1) was cloned by Profs. Dany Deutsch and Aharon Palmon from the Hebrew University-Hadassah School of Dental Medicine in Jerusalem.[2]

Interactions

Tuftelin has been shown to interact with TFIP11.[5]

References

  1. ^ "Entrez Gene: TUFT1 tuftelin 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7286. 
  2. ^ a b Deutsch D, Palmon A, Young MF, Selig S, Kearns WG, Fisher LW (July 1994). "Mapping of the human tuftelin (TUFT1) gene to chromosome 1 by fluorescence in situ hybridization". Mamm. Genome 5 (7): 461–2. doi:10.1007/BF00357011. PMID 7919663. 
  3. ^ Deutsch D (June 1989). "Structure and function of enamel gene products". Anat. Rec. 224 (2): 189–210. doi:10.1002/ar.1092240209. PMID 2672884. 
  4. ^ Deutsch D, Palmon A, Fisher LW, Kolodny N, Termine JD, Young MF (August 1991). "Sequencing of bovine enamelin ("tuftelin") a novel acidic enamel protein". J. Biol. Chem. 266 (24): 16021–8. PMID 1874744. http://www.jbc.org/cgi/content/abstract/266/24/16021. 
  5. ^ Paine, C T; Paine M L, Luo W, Okamoto C T, Lyngstadaas S P, Snead M L (Jul. 2000). "A tuftelin-interacting protein (TIP39) localizes to the apical secretory pole of mouse ameloblasts". J. Biol. Chem. (UNITED STATES) 275 (29): 22284–92. doi:10.1074/jbc.M000118200. ISSN 0021-9258. PMID 10806191. 

Further reading