Systematic (IUPAC) name | |
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1-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5- (trifluoromethyl) pyrimidine-2,4-dione | |
Clinical data | |
Trade names | Viroptic |
AHFS/Drugs.com | monograph |
Pregnancy cat. | ? |
Legal status | ℞ Prescription only |
Routes | Eye drops |
Pharmacokinetic data | |
Half-life | 12 minutes |
Identifiers | |
CAS number | 70-00-8 |
ATC code | S01AD02 |
PubChem | CID 6256 |
DrugBank | APRD01275 |
ChemSpider | 6020 |
UNII | RMW9V5RW38 |
KEGG | D00391 |
ChEMBL | CHEMBL1129 |
Chemical data | |
Formula | C10H11F3N2O5 |
Mol. mass | 296.2 g/mol |
SMILES | eMolecules & PubChem |
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(what is this?)
Trifluridine (also called trifluorothymidine or TFT) is an anti-herpesvirus antiviral drug, used primarily on the eye. It was sold under the trade name, Viroptic, by Glaxo Wellcome, now merged into GlaxoSmithKline. The brand is now owned by Monarch Pharmaceuticals, which is wholly owned by King Pharmaceuticals.
It is a nucleoside analogue, a modified form of deoxyuridine, similar enough to be incorporated into viral DNA replication, but the -CF3 group added to the uracil component blocks base pairing.
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