Trifluridine

Trifluridine
Systematic (IUPAC) name
1-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5- (trifluoromethyl) pyrimidine-2,4-dione
Clinical data
Trade names Viroptic
AHFS/Drugs.com monograph
Pregnancy cat.  ?
Legal status Prescription only
Routes Eye drops
Pharmacokinetic data
Half-life 12 minutes
Identifiers
CAS number 70-00-8 Y
ATC code S01AD02
PubChem CID 6256
DrugBank APRD01275
ChemSpider 6020 Y
UNII RMW9V5RW38 Y
KEGG D00391 N
ChEMBL CHEMBL1129 Y
Chemical data
Formula C10H11F3N2O5 
Mol. mass 296.2 g/mol
SMILES eMolecules & PubChem
 N(what is this?)  (verify)

Trifluridine (also called trifluorothymidine or TFT) is an anti-herpesvirus antiviral drug, used primarily on the eye. It was sold under the trade name, Viroptic, by Glaxo Wellcome, now merged into GlaxoSmithKline. The brand is now owned by Monarch Pharmaceuticals, which is wholly owned by King Pharmaceuticals.

It is a nucleoside analogue, a modified form of deoxyuridine, similar enough to be incorporated into viral DNA replication, but the -CF3 group added to the uracil component blocks base pairing.

External links