Transcription elongation regulator 1

PDB rendering based on 1e0l.

Available structures
PDB	2DK7, 2DOD, 2DOE, 2DOF, 2E71, 2KIQ, 2KIS, 2NNT, 3HFH

Identifiers

Symbols

TCERG1; CA150; MGC133200; TAF2S; Urn1

External IDs

OMIM: 605409 MGI: 1926421 HomoloGene: 4879 GeneCards: TCERG1 Gene

Gene Ontology
Molecular function	• transcription coactivator activity • protein binding
Cellular component	• nucleus
Biological process	• regulation of transcription, DNA-dependent • transcription from RNA polymerase II promoter
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 5:
145.83 – 145.89 Mb

Chr 18:
42.67 – 42.74 Mb

PubMed search

[1]

[2]

Transcription elongation regulator 1, also known as TCERG1, is a protein which in humans is encoded by the TCERG1 gene.^[1]^[2]^[3]

1 Function
2 Interactions
3 References
4 Further reading

Function

This gene encodes a nuclear protein that regulates transcriptional elongation and pre-mRNA splicing. The encoded protein interacts with the hyperphosphorylated C-terminal domain of RNA polymerase II via multiple FF domains, and with the pre-mRNA splicing factor SF1 via a WW domain. Alternative splicing results in multiple transcripts variants encoding different isoforms.^[1]

Interactions

Transcription elongation regulator 1 has been shown to interact with SF1^[4] and POLR2A.^[5]

References

^ ^a ^b "Entrez Gene: TCERG1 transcription elongation regulator 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10915.
^ Suñé C, Hayashi T, Liu Y, Lane WS, Young RA, Garcia-Blanco MA (October 1997). "CA150, a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1 transcription". Molecular and Cellular Biology 17 (10): 6029–39. PMC 232452. PMID 9315662. http://mcb.asm.org/cgi/content/abstract/17/10/6029.
^ Bohne J, Cole SE, Suñe C, Lindman BR, Ko VD, Vogt TF, Garcia-Blanco MA (October 2000). "Expression analysis and mapping of the mouse and human transcriptional regulator CA150". Mammalian Genome : Official Journal of the International Mammalian Genome Society 11 (10): 930–3. doi:10.1007/s003350010162. PMID 11003711.
^ Goldstrohm, A C; Albrecht T R, Suñé C, Bedford M T, Garcia-Blanco M A (Nov. 2001). "The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1". Mol. Cell. Biol. (United States) 21 (22): 7617–28. doi:10.1128/MCB.21.22.7617-7628.2001. ISSN 0270-7306. PMC 99933. PMID 11604498. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=99933.
^ Carty, S M; Goldstrohm A C, Suñé C, Garcia-Blanco M A, Greenleaf A L (Aug. 2000). "Protein-interaction modules that organize nuclear function: FF domains of CA150 bind the phosphoCTD of RNA polymerase II". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (16): 9015–20. doi:10.1073/pnas.160266597. ISSN 0027-8424. PMC 16813. PMID 10908677. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=16813.

Suñé C, Hayashi T, Liu Y, et al. (1997). "CA150, a nuclear protein associated with the RNA polymerase II holoenzyme, is involved in Tat-activated human immunodeficiency virus type 1 transcription". Mol. Cell. Biol. 17 (10): 6029–39. PMC 232452. PMID 9315662. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=232452.
Neubauer G, King A, Rappsilber J, et al. (1998). "Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex". Nat. Genet. 20 (1): 46–50. doi:10.1038/1700. PMID 9731529.
Suñé C, Garcia-Blanco MA (1999). "Transcriptional cofactor CA150 regulates RNA polymerase II elongation in a TATA-box-dependent manner". Mol. Cell. Biol. 19 (7): 4719–28. PMC 84270. PMID 10373521. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=84270.
Carty SM, Goldstrohm AC, Suñé C, et al. (2000). "Protein-interaction modules that organize nuclear function: FF domains of CA150 bind the phosphoCTD of RNA polymerase II". Proc. Natl. Acad. Sci. U.S.A. 97 (16): 9015–20. doi:10.1073/pnas.160266597. PMC 16813. PMID 10908677. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=16813.
Bohne J, Cole SE, Suñe C, et al. (2000). "Expression analysis and mapping of the mouse and human transcriptional regulator CA150". Mamm. Genome 11 (10): 930–3. doi:10.1007/s003350010162. PMID 11003711.
Holbert S, Denghien I, Kiechle T, et al. (2001). "The Gln-Ala repeat transcriptional activator CA150 interacts with huntingtin: neuropathologic and genetic evidence for a role in Huntington's disease pathogenesis". Proc. Natl. Acad. Sci. U.S.A. 98 (4): 1811–6. doi:10.1073/pnas.041566798. PMC 29339. PMID 11172033. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=29339.
Goldstrohm AC, Albrecht TR, Suñé C, et al. (2001). "The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1". Mol. Cell. Biol. 21 (22): 7617–28. doi:10.1128/MCB.21.22.7617-7628.2001. PMC 99933. PMID 11604498. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=99933.
Zhou Z, Licklider LJ, Gygi SP, Reed R (2002). "Comprehensive proteomic analysis of the human spliceosome". Nature 419 (6903): 182–5. doi:10.1038/nature01031. PMID 12226669.
Carty SM, Greenleaf AL (2003). "Hyperphosphorylated C-terminal repeat domain-associating proteins in the nuclear proteome link transcription to DNA/chromatin modification and RNA processing". Mol. Cell Proteomics 1 (8): 598–610. doi:10.1074/mcp.M200029-MCP200. PMID 12376575.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Chattopadhyay B, Ghosh S, Gangopadhyay PK, et al. (2003). "Modulation of age at onset in Huntington's disease and spinocerebellar ataxia type 2 patients originated from eastern India". Neurosci. Lett. 345 (2): 93–6. doi:10.1016/S0304-3940(03)00436-1. PMID 12821179.
Reuter TY, Medhurst AL, Waisfisz Q, et al. (2003). "Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport". Exp. Cell Res. 289 (2): 211–21. doi:10.1016/S0014-4827(03)00261-1. PMID 14499622.
Palancade B, Marshall NF, Tremeau-Bravard A, et al. (2004). "Dephosphorylation of RNA polymerase II by CTD-phosphatase FCP1 is inhibited by phospho-CTD associating proteins". J. Mol. Biol. 335 (2): 415–24. doi:10.1016/j.jmb.2003.10.036. PMID 14672652.
Nagel JE, Smith RJ, Shaw L, et al. (2005). "Identification of genes differentially expressed in T cells following stimulation with the chemokines CXCL12 and CXCL10". BMC Immunol. 5: 17. doi:10.1186/1471-2172-5-17. PMC 514893. PMID 15296517. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=514893.
Goehler H, Lalowski M, Stelzl U, et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Mol. Cell 15 (6): 853–65. doi:10.1016/j.molcel.2004.09.016. PMID 15383276.
Lin KT, Lu RM, Tarn WY (2004). "The WW domain-containing proteins interact with the early spliceosome and participate in pre-mRNA splicing in vivo". Mol. Cell. Biol. 24 (20): 9176–85. doi:10.1128/MCB.24.20.9176-9185.2004. PMC 517884. PMID 15456888. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=517884.
Smith MJ, Kulkarni S, Pawson T (2004). "FF domains of CA150 bind transcription and splicing factors through multiple weak interactions". Mol. Cell. Biol. 24 (21): 9274–85. doi:10.1128/MCB.24.21.9274-9285.2004. PMC 522232. PMID 15485897. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=522232.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1356129.
McFie PJ, Wang GL, Timchenko NA, et al. (2006). "Identification of a co-repressor that inhibits the transcriptional and growth-arrest activities of CCAAT/enhancer-binding protein alpha". J. Biol. Chem. 281 (26): 18069–80. doi:10.1074/jbc.M512734200. PMID 16644732.

PDB gallery

1e0l: FBP28WW DOMAIN FROM MUS MUSCULUS

2dk7: Solution structure of WW domain in transcription elongation regulator 1

2dod: Solution structure of the first FF domain of human transcription factor CA150

2doe: Solution structure of the third FF domain of human transcription factor CA150

2dof: Solution structure of the fourth FF domain of human transcription factor CA150

2nnt: General structural motifs of amyloid protofilaments

Transcription elongation regulator 1

Contents

Function

Interactions

References

Further reading