Torasemide

Torasemide


Systematic (IUPAC) name
N-[(isopropylamino)carbonyl]-4-[(3-methylphenyl)amino]pyridine-3-sulfonamide
Clinical data
AHFS/Drugs.com	International Drug Names
MedlinePlus	a601212
Pregnancy cat.	C(US)
Legal status	℞-only (US)
Routes	Oral, IV
Pharmacokinetic data
Bioavailability	80-90%
Protein binding	Highly bound (>99%).
Metabolism	Hepatic (80%)
Half-life	3.5 hours; Cirrhosis: 7-8 hours
Identifiers
CAS number	56211-40-6
ATC code	C03CA04
PubChem	CID 41781
DrugBank	APRD00217
ChemSpider	38123^Y
UNII	W31X2H97FB^Y
KEGG	D00382^Y
ChEMBL	CHEMBL1148^Y
Chemical data
Formula	C₁₆H₂₀N₄O₃S
Mol. mass	348.421 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C16H20N4O3S/c1-11(2)18-16(21)20-24(22,23)15-10-17-8-7-14(15)19-13-6-4-5-12(3)9-13/h4-11H,1-3H3,(H,17,19)(H2,18,20,21)^Y Key:NGBFQHCMQULJNZ-UHFFFAOYSA-N^Y
Y(what is this?) (verify)

Torasemide (rINN) or torsemide (USAN) is a pyridine-sulfonyl urea type loop diuretic mainly used in the management of edema associated with congestive heart failure. It is also used at low doses for the management of hypertension. It is marketed under the brand name Demadex and Diuver.

Compared to other loop diuretics, torasemide has a more prolonged diuretic effect than equipotent doses of furosemide and relatively decreased potassium-loss. There is no evidence of torasemide-induced ototoxicity demonstrated in humans ^[1].

References

^ Dunn CJ, Fitton A, Brogden RN (January 1995). "Torasemide. An update of its pharmacological properties and therapeutic efficacy". Drugs 49 (1): 121–42. PMID 7705212.

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External links

Medlineplus drug information: Torsemide (Systemic) – information from USP DI Advice for the Patient

Antihypertensives: diuretics (C03)

Sulfonamides
(except EA)

CA inhibitors (at PT)	Acetazolamide

Loop (Na-K-Cl at AL)	Furosemide^# • Bumetanide • Torasemide • Etacrynic acid

Thiazides (Na-Cl at DCT, Calcium-sparing)	Hydrochlorothiazide^# • Bendroflumethiazide • Hydroflumethiazide • Chlorothiazide • Polythiazide • Trichlormethiazide • Cyclopenthiazide • Methyclothiazide • Cyclothiazide • Mebutizide

Thiazide-likes (primarily DCT)	Quinethazone • Clopamide • Chlortalidone • Mefruside • Clofenamide • Metolazone • Meticrane • Xipamide • Indapamide • Clorexolone • Fenquizone

Potassium-sparing (at CD)

ESC blockers	Amiloride^# • Triamterene • Benzamil

Aldosterone antagonists	Spironolactone^# • Eplerenone • Potassium canrenoate • Canrenone

Osmotic diuretics (PT, DL)

Mannitol^# • Urea

VAs (DCT and CD)

vaptans: Conivaptan • Mozavaptan • Satavaptan • Tolvaptan

tetracyclines: Demeclocycline

Other

mercurial diuretic (Mersalyl) • Theobromine • Cicletanine

^#WHO-EM. ^‡Withdrawn from market. Clinical trials: ^†Phase III. ^§Never to phase III

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