Systematic (IUPAC) name | |
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2-methyl-1-(4-methylphenyl)-3-(1-piperidyl)propan-1-one | |
Clinical data | |
AHFS/Drugs.com | International Drug Names |
Pregnancy cat. | ? |
Legal status | ? |
Identifiers | |
CAS number | 728-88-1 |
ATC code | M03BX04 |
PubChem | CID 5511 |
UNII | F5EOM0LD8E |
KEGG | D08617 |
Chemical data | |
Formula | C16H23NO |
Mol. mass | 245.36 g/mol |
SMILES | eMolecules & PubChem |
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Tolperisone, a piperidine derivative, is a centrally-acting muscle relaxant. Trade names include Biocalm,Muscodol, Mydeton, Mydocalm, Myolax, Myoxan and Viveo.
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Typically, tolperisone is indicated in the treatment of acute muscle spasms in back pain and spasticity in neurological diseases.
Tolperisone is currently marketed in Europe as a centrally-acting muscle relaxant, which reportedly has special advantages over other drugs of its class, in that it reportedly does not cause drowsiness or lethargy, according to some manufacturers.[1]
Besides claiming "tolperisone has an excellent efficacy and safety profile", these manufacturers also state[1] tolperisone has the unique property of mediating muscle relaxation "without concomitant sedation" and it does not cause incoordination, weakness, mental confusion or withdrawal phenomena, in contrast to other muscle relaxants.
Tolperisone is reportedly used in the typical treatment of the following conditions:
Manufacturers report that tolperisone should not be used in the following conditions:
Some people using tolperisone have reported[2] the following reactions:
The side effects and reactions listed above may not include all effects reported by the drug's manufacturer.
Tolperisone is believed to have few interactions with other medicines, but this does not rule out any interactions that may not have been reported to caregivers thus far.
Some manufacturers have stated tolperisone may enhance the effects of other neuromuscular blocking agents.
According to various sources, the typical oral adult dose for tolperisone is 150-450 mg in a 24-hour period, divided into two or three portions. It is highly advised that dosage information be confirmed by information provided from the manufacturer and prescriber.
More detailed dosage information[3] is as follows:
Adults over 12 years old:
Pediatric dosage (minimum weight of 20 kg, minimum age 6 years):
Neonatal dosage (minimum weight of 3 kg)
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