Tixocortol

Tixocortol

Systematic (IUPAC) name
(11β)-11,17-dihydroxy-21-mercaptopregn-4-ene-3,20-dione
Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	61951-99-3
ATC code	A07EA05 R01AD07
PubChem	CID 162955
ChemSpider	143053^Y
UNII	ZX3KEK657Z^Y
KEGG	D08610^Y
Synonyms	(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-mercaptoacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one
Chemical data
Formula	C₂₁H₃₀O₄S
Mol. mass	378.527 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C21H30O4S/c1-19-7-5-13(22)9-12(19)3-4-14-15-6-8-21(25,17(24)11-26)20(15,2)10-16(23)18(14)19/h9,14-16,18,23,25-26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1^Y Key:YWDBSCORAARPPF-VWUMJDOOSA-N^Y
Y(what is this?) (verify)

Tixocortol is a corticosteroid used as an intestinal anti-inflammatory and decongestant.

Pregnene	CORTISONE

Pregnenedione (+20-one)	HYDROCORTISONE/CORTISOL^# (Hydrocortisone aceponate, Hydrocortisone buteprate, Hydrocortisone butyrate) • Budesonide • Ciclesonide • Deflazacort • Medrysone • Tixocortol • HALOGENATED AT 6: Cloprednol • HALOGENATED, WITH FG AT 16: Halcinonide

Pregnadiene (+1-ene)	Rimexolone • HALOGENATED, WITH FG AT 16: Flunisolide • Triamcinolone • Amcinonide • Fluocinolone acetonide (Fluocinonide)

Pregnadienediol (+21-hydroxy)	Prednisone (Meprednisone) • HALOGENATED AT 9: Fluorometholone • HALOGENATED, WITH FG AT 16: Fluocortolone (Clocortolone, Diflucortolone, Fluocortin) • Desoximetasone

Pregnadienetriol (+11-hydroxy)	Prednisolone^# (Methylprednisolone, Methylprednisolone aceponate, Prednicarbate, Prednylidene) • Desonide • HALOGENATED: Fluprednisolone (Difluprednate, Fluperolone) • HALOGENATED, WITH FG AT 16: Dexamethasone^# • Betamethasone (Clobetasol, Clobetasone, Diflorasone, Halometasone, Ulobetasol) • Beclometasone • Paramethasone • Alclometasone • Fluclorolone • Flumetasone • Fluprednidene

Pregnatriene (+2-ene)	Cortivazol

Androstene	HALOGENATED, WITH FG AT 16: Fluticasone (Fluticasone propionate, Fluticasone furoate)

Other/ungrouped	HALOGENATED: Loteprednol • HALOGENATED, WITH FG AT 16: Fludroxycortide • Formocortal • Mometasone furoate

Aldosterone antagonists

Spironolactone • Eplerenone • Potassium canrenoate • Canrenone

Synthesis modifiers

Trilostane • Carbenoxolone • Aminoglutethimide • Metyrapone

^#WHO-EM. ^‡Withdrawn from market. Clinical trials: ^†Phase III. ^§Never to phase III

M: END

anat/phys/devp/horm

noco(d)/cong/tumr, sysi/epon

proc, drug (A10/H1/H2/H3/H5)

Antidiarrheals, intestinal anti-inflammatory/anti-infective agents (A07)

Rehydration

Oral rehydration therapy

Intestinal anti-infectives

Antibiotics (Neomycin, Nystatin, Natamycin, Streptomycin, Polymyxin B, Paromomycin, Amphotericin B, Kanamycin, Vancomycin, Colistin, Rifaximin)

Sulfonamides (Phthalylsulfathiazole, Sulfaguanidine, Succinylsulfathiazole)

Nitrofuran (Nifuroxazide, Nifurzide)

Imidazole (Miconazole)

Arsenical (Acetarsol)

Oxyquinoline (Broxyquinoline)

Intestinal adsorbents

Charcoal • Bismuth • Pectin • Kaolin • Crospovidone • Attapulgite • Diosmectite

Antipropulsives (opioids)

Opium Tincture (Laudanum) • Codeine • Morphine • Camphorated Opium Tincture (Paregoric)

crosses BBB: Diphenoxylate (Diphenoxylate/atropine) • Difenoxin

does not cross BBB: Loperamide

Intestinal anti-inflammatory agents

corticosteroids acting locally (Prednisolone, Hydrocortisone, Prednisone, Betamethasone, Tixocortol, Budesonide, Beclometasone)

antiallergic agents, excluding corticosteroids (Cromoglicic acid)

aminosalicylic acid and similar agents (Sulfasalazine, Mesalazine, Olsalazine, Balsalazide)

Antidiarrheal micro-organisms

Saccharomyces boulardii

Other antidiarrheals

Albumin tannate • Ceratonia • Octreotide • Racecadotril

M: DIG

anat(t, g, p)/phys/devp/enzy

noco/cong/tumr, sysi/epon

proc, drug(A2A/2B/3/4/5/6/7/14/16), blte

Decongestants and other nasal preparations (R01)

Topical

Sympathomimetics, plain	Cyclopentamine • Ephedrine • Phenylephrine • Oxymetazoline • Tetryzoline • Xylometazoline • Naphazoline • Tramazoline • Metizoline • Tuaminoheptane • Fenoxazoline • Tymazoline • Epinephrine

Antiallergic agents, excluding corticosteroids	Spaglumic acid histamine antagonists (Levocabastine, Antazoline, Thonzylamine) mast cell stabilizer (some are also antihistamines) (Cromoglicic acid, Nedocromil, Azelastine, Olopatadine, Lodoxamide)

Corticosteroids	Beclometasone • Prednisolone • Dexamethasone • Flunisolide • Budesonide • Betamethasone • Tixocortol • Fluticasone • Mometasone furoate • Triamcinolone • Ciclesonide

Other nasal preparations	Cafaminol • Calcium hexamine thiocyanate • Retinol • Ipratropium bromide • Ritiometan • Mupirocin • Hexamidine • Framycetin • Hyaluronic acid • Eucalyptus oil

Systemic use:
Sympathomimetics

Phenylpropanolamine • Pseudoephedrine (+loratadine) • Phenylephrine • Phenylpropylamine

M: RES

anat(n, x, l, c)/phys/devp

noco(c, p)/cong/tumr, sysi/epon, injr

proc, drug(R1/2/3/5/6/7)

Tixocortol

See also