The Tissino River is a small watercourse of eastern Umbria in Italy. Its source is a few hundred meters S of Usigni, at an approximate altitude of 1000 m (3300 ft), and it flows for about 20 km (12 mi), almost due north, past the towns of Usigni, Poggiodomo, Roccatamburo and Mucciafora, high above the river in the massif of Mounts Coscerno and Bacugno on its west bank, then past Rocchetta and Ponte also high above it on the ridge of Monte Maggio on its east bank; and flows into the Nera River at about 380 m (1250 ft) altitude, at about 1 km SW of Cerreto Borgo.
The Tissino is not to be confused with the Tescino, about a dozen kilometers away, that flows into the Nera at Terni; nor with the Ticino, a large river of northern Italy.