Tigemonam

Tigemonam
IUPAC name

2-[[1-(2-Amino-1,3-thiazol-4-yl)- 2-[[(3S)-2,2-dimethyl-4-oxo-1- sulfooxyazetidin-3-yl]amino]-2- oxoethylidene]amino]oxyacetic acid
Identifiers
CAS number 102507-71-1
PubChem 9576769
Jmol-3D images Image 1
Properties
Molecular formula C12H15N5O9S2
Molar mass 437.4056
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Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Tigemonam is a monobactam antibiotic.[1][2]

References

  1. ^ Fuchs PC, Jones RN, Barry AL (March 1988). "In vitro antimicrobial activity of tigemonam, a new orally administered monobactam". Antimicrob. Agents Chemother. 32 (3): 346–9. PMC 172173. PMID 3259122. http://aac.asm.org/cgi/pmidlookup?view=long&pmid=3259122. 
  2. ^ Chin NX, Neu HC (January 1988). "Tigemonam, an oral monobactam". Antimicrob. Agents Chemother. 32 (1): 84–91. PMC 172104. PMID 3279906. http://aac.asm.org/cgi/pmidlookup?view=long&pmid=3279906. 
Intracellular
inhibit peptidoglycan subunit synthesis and transport: NAM synthesis inhibition (Fosfomycin) • DADAL/AR inhibitors (Cycloserine) • bactoprenol inhibitors (Bacitracin)
Glycopeptide
inhibit PG chain elongation: Vancomycin# (Oritavancin, Telavancin) • Teicoplanin (Dalbavancin) • Ramoplanin
β-lactams/
(inhibit PBP
cross-links)
Aztreonam • Tigemonam • Carumonam • Nocardicin A
Combinations
Other

M: BAC

bact (clas)

gr+f/gr+a(t)/gr-p(c)/gr-o

drug(J1p, w, n, m, vacc)