Ticlopidine

Ticlopidine
Systematic (IUPAC) name
5-(2-chlorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine
Clinical data
Trade names Ticlid
AHFS/Drugs.com monograph
MedlinePlus a695036
Pregnancy cat. B1(AU) C(US)
Legal status  ?
Routes Oral
Pharmacokinetic data
Bioavailability >80%
Protein binding 98%
Metabolism Hepatic
Half-life *12 hours (single dose)
Excretion Renal and fecal
Identifiers
CAS number 55142-85-3 Y
ATC code B01AC05
PubChem CID 5472
DrugBank APRD01257
ChemSpider 5273 Y
UNII OM90ZUW7M1 Y
KEGG D08594 Y
ChEBI CHEBI:9588 N
ChEMBL CHEMBL833 Y
Chemical data
Formula C14H14ClNS 
Mol. mass 263.786 g/mol
SMILES eMolecules & PubChem
 N(what is this?)  (verify)

Ticlopidine (trade name Ticlid) is an antiplatelet drug in the thienopyridine family. Like clopidogrel, it is an adenosine diphosphate (ADP) receptor inhibitor. It is used in patients in whom aspirin is not tolerated, or in whom dual antiplatelet therapy is desirable. Because it has been reported to increase the risk of thrombotic thrombocytopenic purpura (TTP) and neutropenia, its use has largely been supplanted by the newer drug, clopidogrel, which is felt to have a much lower hematologic risk. The usual dose is 250 mg twice daily by the oral route.

Action

Contraindications

Precautions