Systematic (IUPAC) name | |
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17-Hydroxy-7α-methyl-19-nor-17α-pregn-5(10)-en-20-yn-3-one | |
Clinical data | |
AHFS/Drugs.com | International Drug Names |
Pregnancy cat. | ADEC Category D |
Legal status | ? |
Routes | oral |
Identifiers | |
CAS number | 5630-53-5 |
ATC code | G03CX01 |
PubChem | CID 444008 |
ChemSpider | 392038 |
UNII | FF9X0205V2 |
KEGG | D01639 |
ChEBI | CHEBI:32223 |
ChEMBL | CHEMBL1558898 |
Synonyms | (7α,17β)-17-ethynyl-17-hydroxy-7-methylestr-5(10)-en-3-one |
Chemical data | |
Formula | C21H28O2 |
Mol. mass | 312.446 g/mol |
SMILES | eMolecules & PubChem |
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Tibolone is a synthetic steroid hormone drug, which is fairly non-selective in its binding profile, acting as an agonist at all five of the Type I steroid hormone receptors.[1] It is used mainly for treatment of endometriosis,[2] as well as hormone replacement therapy in post-menopausal women. Tibolone has similar or greater efficacy compared to older hormone replacement drugs, but shares a similar side effect profile.[3][4][5] It has also been investigated as a possible treatment for female sexual dysfunction,[6] although it is unclear whether the benefits in this application justify the known risks of the drug.
A report in September 2009 from Health and Human Services' Agency for Healthcare Research and Quality suggests that tamoxifen, raloxifene, and tibolone used to treat breast cancer significantly reduce invasive breast cancer in midlife and older women, but also increase the risk of adverse side effects.[7]
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