Tiazofurin

Tiazofurin

Systematic (IUPAC) name
(1R)-1-[4-(aminocarbonyl)-1,3-thiazol-2-yl]-1,4-anhydro-D-ribitol
Clinical data
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	60084-10-8
ATC code	L01XX18
PubChem	CID 457954
ChemSpider	403014^Y
UNII	ULJ82834RE^Y
ChEMBL	CHEMBL108358^Y
Synonyms	2-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3-thiazole-4-carboxamide
Chemical data
Formula	C₉H₁₂N₂O₅S
Mol. mass	260.268 g/mol
SMILES	eMolecules & PubChem
InChI InChI=1S/C9H12N2O5S/c10-8(15)3-2-17-9(11-3)7-6(14)5(13)4(1-12)16-7/h2,4-7,12-14H,1H2,(H2,10,15)/t4-,5-,6-,7-/m1/s1^Y Key:FVRDYQYEVDDKCR-DBRKOABJSA-N^Y
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Tiazofurin is an inhibitor of IMP dehydrogenase. Tiazofurin and its analogues are under investigation for potential use in the treatment of cancer.^[1]

References

^ Popsavin M, Torović L, Svircev M et al. (2006). "Synthesis and antiproliferative activity of two new tiazofurin analogues with 2'-amido functionalities". Bioorg. Med. Chem. Lett. 16 (10): 2773–6. doi:10.1016/j.bmcl.2006.02.001. PMID 16495053.