Thyronamine

Thyronamine


Identifiers
CAS number	500-78-7^Y
PubChem	3083601
ChemSpider	2340781^Y
MeSH	thyronamine
ChEMBL	CHEMBL201896^Y
Jmol-3D images	Image 1
SMILES O(c1ccc(cc1)CCN)c2ccc(O)cc2
InChI InChI=1S/C14H15NO2/c15-10-9-11-1-5-13(6-2-11)17-14-7-3-12(16)4-8-14/h1-8,16H,9-10,15H2^Y Key: OVUVNKDANCKDCK-UHFFFAOYSA-N^Y InChI=1/C14H15NO2/c15-10-9-11-1-5-13(6-2-11)17-14-7-3-12(16)4-8-14/h1-8,16H,9-10,15H2 Key: OVUVNKDANCKDCK-UHFFFAOYAP
Properties
Molecular formula	C₁₄H₁₅NO₂
Molar mass	229.274 g mol⁻¹
Y (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Thyronamine refers both to a molecule, and to derivatives of that molecule: a family of decarboxylated and deiodinated metabolites of the thyroid hormones thyroxine (T4) and 3,5,3'-triiodothyronine (T3).

Types

The group includes:

Thyronamine (T0AM)
3-Iodothyronamine (T1AM), which is the most notable one as it is a trace amine found in the nervous system. It is a possible candidate for the natural ligand of the trace amine-associated receptor TAAR1 (TAR1), a G protein-coupled receptor located in the cell membrane.
3,5-Diiodothyronamine (T2AM)
3,5,3'-Triiodothyronamine (T3AM)

See also

Thyroid hormone metabolic intermediates

Tyrosine / iodotyrosine

Monoiodotyrosine · Diiodotyrosine

Thyronine / iodothyronine

3'-Monoiodothyronine · 3,3'-Diiodothyronine · 3,3',5-Triiodothyronine (T₃) · 3,3',5'-Triiodothyronine (Reverse T₃) · 3,5,3',5'-Tetraiodothyronine (Thyroxine, T₄)

Thyronamine / iodothyronamine

3-Iodothyronamine · 3,3',5-Triiodothyronamine

M: MET

mt, k, c/g/r/p/y/i, f/h/s/l/o/e, a/u, n, m

k, cgrp/y/i, f/h/s/l/o/e, au, n, m, epon

m(A16/C10),i(k, c/g/r/p/y/i, f/h/s/o/e, a/u, n, m)

M: END

anat/phys/devp/horm

noco(d)/cong/tumr, sysi/epon

proc, drug (A10/H1/H2/H3/H5)