| Thirumalaisamudram | |
| — village — | |
| Coordinates | |
| Country | India |
| State | Tamil Nadu |
| District(s) | Thanjavur |
| Panchayat President | |
| Population | 2,332 (2001[update]) |
| Time zone | IST (UTC+05:30) |
Thirumalaisamudram (Tamil: திருமலைசமுத்திரம்)is a village in Thanjavur taluk of Thanjavur district, Tamil Nadu. It is located at a distance of 17 kilometres west of Thanjavur, 5 kilometres from Vallam and 39 kilometres east of Tiruchirapalli on the Thanjavur-Tiruchirapalli highway. It adjoins the neighbouring village of Vallam Pudursethi.
Thirumalaisamudram has risen in importance in recent years due to the emergence of SASTRA University. The university covers most of the north-eastern part of the village. There are also a number of tea shops and restaurants adjoining the college.
As per the 2001 census, Thirumalaisamudram had a population of 2332 with 1445 males and 887 females. The sex ratio was 614 and the literacy rate, 75.13.