In organic chemistry, a semicarbazone is a derivative of an aldehyde or ketone formed by a condensation reaction between a ketone or aldehyde and semicarbazide.
For ketones:
For aldehydes:
For example, the semicarbazone of acetone would have the structure (CH3)2C=NNHC(=O)NH2.
A thiosemicarbazone is an analog of a semicarbazone which contains a sulfur atom in place of the oxygen atom.
Some semicarbazones, such as nitrofurazone, and thiosemicarbazones are known to have anti-viral and anti-cancer activity, usually mediated through binding to copper or iron in cells. Many semicarbazones are crystalline solids, useful for the identification of the parent aldehydes/ketones by melting point analysis.[1]
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