Thiorphan

Thiorphan
Systematic (IUPAC) name
(±)-2-[(2-benzyl-3-sulfanyl-propanoyl)amino]acetic acid
Clinical data
Pregnancy cat.  ?
Legal status  ?
Identifiers
CAS number 76721-89-6
ATC code  ?
PubChem CID 3132
DrugBank 3132
ChemSpider 3020
ChEMBL CHEMBL10247
Chemical data
Formula C12H15NO3S
Mol. mass 253.32 g/mol
SMILES eMolecules & PubChem

Thiorphan is the active metabolite of the antidiarrheal racecadotril (acetorphan).[1] It prevents the degradation of endogenous enkephalins by acting as an enkephalinase inhibitor.[1]

See also

References

  1. ^ a b Spillantini MG, Geppetti P, Fanciullacci M, Michelacci S, Lecomte JM, Sicuteri F (June 1986). "In vivo 'enkephalinase' inhibition by acetorphan in human plasma and CSF". European Journal of Pharmacology 125 (1): 147–50. doi:10.1016/0014-2999(86)90094-4. PMID 3015640. http://linkinghub.elsevier.com/retrieve/pii/0014-2999(86)90094-4.