| Tetramethylenedisulfotetramine[1] | |
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2,6-Dithia- 1,3,5,7- tetraaza- tricyclo [3.3.1.13,7] decane 2,2,6,6-tetraoxide |
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Other names
Tetramine, TETS, DSTA, Dushuqiang, Four-two-four, 424, NSC 172824, Meishuming, Sanbudao |
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| Identifiers | |
| Abbreviations | TETS, DSTA |
| CAS number | 80-12-6 |
| PubChem | 64148 |
| ChemSpider | 57722 |
| Jmol-3D images | Image 1 |
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| Properties | |
| Molecular formula | C4H8N4O4S2 |
| Molar mass | 240.26 g/mol |
| Appearance | White powder |
| Melting point |
255–260 °C |
| Solubility in water | 0.25 mg/mL |
| Hazards | |
| Main hazards | Poison |
| LD50 | 0.20 mg/kg (mice) |
| (verify) (what is: /?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
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| Infobox references | |
Tetramethylenedisulfotetramine is an organic compound that is used as a rodenticide (rat poison).[2] It is an odorless, tasteless white powder that is slightly soluble in water, DMSO and acetone, and insoluble in methanol and ethanol. It is a sulfamide derivative. When crystallized from acetone, it forms cubic crystals with a melting point of 255–260 °C.
TETS is a neurotoxin, causing lethal convulsions. Its effect is similar to picrotoxin, another cage convulsant. As one of the most hazardous pesticides, it is 100x more toxic than potassium cyanide. It might be a more powerful convulsant than strychnine. It is a non-competitive GABA antagonist and binds irreversibly to neuronal GABA receptors and disables chloride channels, activating neurons. No antidote is known. Lethal dose for humans are 7-10 milligrams. Poisoning is diagnosed by gas chromatography and the treatment is mainly supportive, with large doses of benzodiazepines and pyridoxine.[3] It is retained in tissues of poisoned poultry and animals, posing a risk of secondary poisoning.
Its use worldwide has been banned since 1984, but due to continuing demand and its ease of production,[4][5] it is still readily, although illegally, available in China and can be found in some illegally imported rat poisons. The best known Chinese rodenticide, containing about 6-20% TETS, is Dushuqiang, "very strong rat poison". It has been used for mass poisonings in China: in April 2004, there were 74 casualties after eating scallion-flavored pancakes tainted by their vendor's competitor; and in September 2002, 400 people were poisoned and 38 died from contaminated food.[6][7] In 2002, there was one documented case of accidental poisoning in the US.[3]
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