Tetraloop

Tetraloops are a type of four-base hairpin loop motifs in RNA secondary structure that cap many double helices[2]. Three types of tetraloops are common in ribosomal RNA: GNRA, UNCG and CUUG. The GNRA tetraloop has a guanine-adenine base-pair where the guanine is 5' to the helix and the adenine is 3' to the helix.

See also

References

  1. ^ Cate, J.H., Gooding, A.R., Podell, E., Zhou, K., Golden, B.L., Kundrot, C.E., Cech, T.R., Doudna, J.A. (1996). "Crystal structure of a group I ribozyme domain: principles of RNA packing.". Science 273 (5282): 1676–1685. doi:10.1126/science.273.5282.1678. PMID 8781224. 
  2. ^ Woese CR, Winkers S, Gutell RR (1990). "Architecture of ribosomal RNA: Constraints on the sequence of "tetra-loops"". Proc. Nati. Acad. Sci. USA 87 (21): 8467–71. doi:10.1073/pnas.87.21.8467. PMC 54977. PMID 2236056. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=54977.