Telomestatin

Telomestatin

Identifiers
CAS number	265114-54-3^Y
PubChem	11954679
ChEMBL	CHEMBL443683^N
Jmol-3D images	Image 1
SMILES CC1=C(C2=NC(C3=NC(C4=NC(C5=NC(C6=NC(C7=NC(C8=N[C@@]9([H])CS8)=CO7)=CO6)=CO5)=CO4)=CO3)=C(C)O2)N=C9O1
Properties
Molecular formula	C₂₆H₁₄N₈O₇S
Molar mass	582.5 g mol⁻¹
N (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Telomestatin is a macrocyclic chemical compound that acts by inhibiting the telomerase activity of the cancer cells.^[1] It was first isolated from the bacteria Streptomyces anulatus.^[1] Telomestatin induces the formation of basket-type G-quadruplex (G4) structures from hybrid-type G-quadruplexes in the telomeric region. Upon formation of G4 structure there will be a decrease in the activity of the telomerase, which is involved in the replication of the telomeres and as a result the cell dies due to Hayflick type senescence.

References

^ ^a ^b Shin-ya, Kazuo; Wierzba, Konstanty; Matsuo, Ken-ichi; Ohtani, Toshio; Yamada, Yuji; Furihata, Kazuo; Hayakawa, Yoichi; Seto, Haruo (2001). "Telomestatin, a novel telomerase inhibitor from Streptomyces anulatus". Journal of the American Chemical Society 123 (6): 1262–1263. doi:10.1021/ja005780q. PMID 11456694.