Technetium (99mTc) nofetumomab merpentan

Technetium (99mTc) nofetumomab merpentan?
Monoclonal antibody
Type Fab fragment
Source Mouse
Clinical data
Pregnancy cat.  ?
Legal status  ?
Pharmacokinetic data
Half-life 10.5 hours
Excretion renal (64%)
Identifiers
CAS number 165942-79-0 Y
ATC code None
Chemical data
Formula  ?
 N(what is this?)  (verify)

Technetium (99mTc) nofetumomab merpentan (trade name Verluma) is a mouse monoclonal antibody used in the diagnosis of lung cancer[1], gastrointestinal, breast, ovary, pancreas, kidney, cervix, and bladder carcinoma[2]. The antibody itself, nofetumomab, is attached to the chelator merpentan, which links it to the radioisotope technetium-99m (99mTc).[3]

References

  1. ^ Straka, MR; Joyce, JM; Myers, DT (2000). "Tc-99m nofetumomab merpentan complements an equivocal bone scan for detecting skeletal metastatic disease from lung cancer". Clinical nuclear medicine 25 (1): 54–5. PMID 10634533. 
  2. ^ Breitz, HB; Tyler, A; Bjorn, MJ; Lesley, T; Weiden, PL (1997). "Clinical experience with Tc-99m nofetumomab merpentan (Verluma) radioimmunoscintigraphy". Clinical nuclear medicine 22 (9): 615–20. PMID 9298295. 
  3. ^ WHO Drug Information
Tumor ("-t(u[m])-")
Human ("-tumu-")
Mouse ("-tumo-")
Chimeric ("-tuxi-")
Humanized ("-tuzu-")
Rat/mouse hybrid ("-tumaxo-")