TXN2

Thioredoxin 2

PDB rendering based on 1uvz.

Available structures
PDB	1UVZ, 1W4V, 1W89

Identifiers

Symbols

TXN2; MT-TRX; MTRX; TRX2

External IDs

OMIM: 609063 MGI: 1929468 HomoloGene: 40849 GeneCards: TXN2 Gene

Gene Ontology
Molecular function	• peptide-methionine-(S)-S-oxide reductase activity • electron carrier activity • protein disulfide oxidoreductase activity • protein complex binding • peptide-methionine (R)-S-oxide reductase activity
Cellular component	• nucleolus • mitochondrion
Biological process	• response to hypoxia • glycerol ether metabolic process • transport • response to oxidative stress • response to nutrient • response to hormone stimulus • response to glucose stimulus • response to organic cyclic compound • electron transport chain • cellular response to nutrient levels • response to drug • cell redox homeostasis • response to axon injury
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 22:
36.86 – 36.88 Mb

Chr 15:
77.75 – 77.76 Mb

PubMed search

[1]

[2]

Thioredoxin, mitochondrial is a protein that in humans is encoded by the TXN2 gene.^[1]^[2]^[3]

This nuclear gene encodes a mitochondrial member of the thioredoxin family, a group of small multifunctional redox-active proteins. The encoded protein may play important roles in the regulation of the mitochondrial membrane potential and in protection against oxidant-induced apoptosis.^[3]

References

^ Spyrou G, Enmark E, Miranda-Vizuete A, Gustafsson J (Mar 1997). "Cloning and expression of a novel mammalian thioredoxin". J Biol Chem 272 (5): 2936–41. doi:10.1074/jbc.272.5.2936. PMID 9006939.
^ Zhou J, Damdimopoulos AE, Spyrou G, Brune B (Mar 2007). "Thioredoxin 1 and thioredoxin 2 have opposed regulatory functions on hypoxia-inducible factor-1alpha". J Biol Chem 282 (10): 7482–90. doi:10.1074/jbc.M608289200. PMID 17220299.
^ ^a ^b "Entrez Gene: TXN2 thioredoxin 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25828.

Wang Z, Zhang H, Li XF, Le XC (2007). "Study of interactions between arsenicals and thioredoxins (human and E. coli) using mass spectrometry". Rapid Commun. Mass Spectrom. 21 (22): 3658–66. doi:10.1002/rcm.3263. PMID 17939155.
Udler M, Maia AT, Cebrian A, et al. (2007). "Common germline genetic variation in antioxidant defense genes and survival after diagnosis of breast cancer". J. Clin. Oncol. 25 (21): 3015–23. doi:10.1200/JCO.2006.10.0099. PMID 17634480.
Zhang H, Go YM, Jones DP (2007). "Mitochondrial thioredoxin-2/peroxiredoxin-3 system functions in parallel with mitochondrial GSH system in protection against oxidative stress". Arch. Biochem. Biophys. 465 (1): 119–26. doi:10.1016/j.abb.2007.05.001. PMID 17548047.
Oestergaard MZ, Tyrer J, Cebrian A, et al. (2006). "Interactions between genes involved in the antioxidant defence system and breast cancer risk". Br. J. Cancer 95 (4): 525–31. doi:10.1038/sj.bjc.6603272. PMC 2360671. PMID 16868544. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2360671.
Cebrian A, Pharoah PD, Ahmed S, et al. (2006). "Tagging single-nucleotide polymorphisms in antioxidant defense enzymes and susceptibility to breast cancer". Cancer Res. 66 (2): 1225–33. doi:10.1158/0008-5472.CAN-05-1857. PMID 16424062.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=545604.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Damdimopoulos AE, Miranda-Vizuete A, Pelto-Huikko M, et al. (2002). "Human mitochondrial thioredoxin. Involvement in mitochondrial membrane potential and cell death". J. Biol. Chem. 277 (36): 33249–57. doi:10.1074/jbc.M203036200. PMID 12080052.
Chen Y, Cai J, Murphy TJ, Jones DP (2002). "Overexpressed human mitochondrial thioredoxin confers resistance to oxidant-induced apoptosis in human osteosarcoma cells". J. Biol. Chem. 277 (36): 33242–8. doi:10.1074/jbc.M202026200. PMID 12032145.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.

PDB gallery

1uvz: STRUCTURE OF HUMAN THIOREDOXIN 2

1w4v: STRUCTURE OF THE OXIDISED FORM OF HUMAN THIOREDOXIN 2

1w89: STRUCTURE OF THE REDUCED FORM OF HUMAN THIOREDOXIN 2

TXN2

References

Further reading