TUBGCP6

Tubulin, gamma complex associated protein 6

Identifiers

External IDs

OMIM: 610053 HomoloGene: 32477 GeneCards: TUBGCP6 Gene

Gene Ontology
Molecular function	• microtubule binding
Cellular component	• spindle pole • cytoplasm • centrosome • cytosol • cytoskeleton • microtubule • gamma-tubulin ring complex
Biological process	• G2/M transition of mitotic cell cycle • mitotic cell cycle • microtubule nucleation
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

n/a

ENSG00000128159

n/a

n/a

RefSeq (mRNA)

n/a

RefSeq (protein)

n/a

Location (UCSC)

Chr 22:
50.66 – 50.68 Mb

n/a

PubMed search

n/a

Gamma-tubulin complex component 6 is a protein that in humans is encoded by the TUBGCP6 gene.^[1]^[2]^[3]

The protein encoded by this gene is part of a large multisubunit complex required for microtubule nucleation at the centrosome.^[3]

References

^ Murphy SM, Preble AM, Patel UK, O'Connell KL, Dias DP, Moritz M, Agard D, Stults JT, Stearns T (Nov 2001). "GCP5 and GCP6: two new members of the human gamma-tubulin complex". Mol Biol Cell 12 (11): 3340–52. PMC 60259. PMID 11694571. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=60259.
^ Hirosawa M, Nagase T, Murahashi Y, Kikuno R, Ohara O (Mar 2001). "Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping". DNA Res 8 (1): 1–9. doi:10.1093/dnares/8.1.1. PMID 11258795.
^ ^a ^b "Entrez Gene: TUBGCP6 tubulin, gamma complex associated protein 6". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=85378.

Further reading

Oriolo AS, Wald FA, Canessa G, Salas PJ (2007). "GCP6 binds to intermediate filaments: a novel function of keratins in the organization of microtubules in epithelial cells". Mol. Biol. Cell 18 (3): 781–94. doi:10.1091/mbc.E06-03-0201. PMC 1805110. PMID 17182859. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1805110.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=514446.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.