TUBG2

Tubulin, gamma 2

PDB rendering based on 1z5v.

Available structures
PDB	1z5v, 1z5w

Identifiers

TUBG2; MGC131994

External IDs

OMIM: 605785 MGI: 2144208 HomoloGene: 69216 GeneCards: TUBG2 Gene

Gene Ontology
Molecular function	• nucleotide binding • GTPase activity • structural molecule activity • GTP binding
Cellular component	• pericentriolar material • cytoplasm • cytosol • spindle microtubule • cytoplasmic microtubule • microtubule cytoskeleton
Biological process	• G2/M transition of mitotic cell cycle • mitotic cell cycle • microtubule-based process • protein polymerization
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000037042

ENSMUSG00000045007

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 17:
40.81 – 40.82 Mb

Chr 11:
101.02 – 101.02 Mb

PubMed search

Tubulin gamma-2 chain is a protein that in humans is encoded by the TUBG2 gene.^[1]

References

^ "Entrez Gene: TUBG2 tubulin, gamma 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27175.

Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Tassin AM, Celati C, Moudjou M, Bornens M (1998). "Characterization of the human homologue of the yeast spc98p and its association with gamma-tubulin". J. Cell Biol. 141 (3): 689–701. doi:10.1083/jcb.141.3.689. PMC 2132749. PMID 9566969. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2132749.
Herreros L, Rodríguez-Fernandez JL, Brown MC, et al. (2000). "Paxillin localizes to the lymphocyte microtubule organizing center and associates with the microtubule cytoskeleton". J. Biol. Chem. 275 (34): 26436–40. doi:10.1074/jbc.M003970200. PMID 10840040.
Wise DO, Krahe R, Oakley BR (2000). "The gamma-tubulin gene family in humans". Genomics 67 (2): 164–70. doi:10.1006/geno.2000.6247. PMID 10903841.
Niwa J, Ishigaki S, Doyu M, et al. (2001). "A novel centrosomal ring-finger protein, dorfin, mediates ubiquitin ligase activity". Biochem. Biophys. Res. Commun. 281 (3): 706–13. doi:10.1006/bbrc.2001.4414. PMID 11237715.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Chang F, Re F, Sebastian S, et al. (2004). "HIV-1 Vpr induces defects in mitosis, cytokinesis, nuclear structure, and centrosomes". Mol. Biol. Cell 15 (4): 1793–801. doi:10.1091/mbc.E03-09-0691. PMC 379276. PMID 14767062. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=379276.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

PDB gallery

1z5v: Crystal structure of human gamma-tubulin bound to GTPgammaS

1z5w: Crystal Structure of gamma-tubulin bound to GTP