TUBB2C

Tubulin, beta 2C

PDB rendering based on 1ffx.

Available structures
PDB	1ffx, 1ia0, 1jff, 1sa0, 1sa1, 1tub, 1tvk, 1z2b, 2hxf, 2hxh

Identifiers

TUBB2C; Beta2; TUBB2

External IDs

OMIM: 602660 MGI: 1915472 HomoloGene: 68504 GeneCards: TUBB2C Gene

Gene Ontology
Molecular function	• nucleotide binding • GTPase activity • structural molecule activity • GTP binding • MHC class I protein binding • unfolded protein binding
Cellular component	• cytoplasm • cytosol • cytoskeleton • microtubule
Biological process	• G2/M transition of mitotic cell cycle • mitotic cell cycle • protein folding • cellular component movement • microtubule-based movement • natural killer cell mediated cytotoxicity • cellular protein metabolic process • 'de novo' posttranslational protein folding • protein polymerization
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000188229

ENSMUSG00000036752

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 9:
140.14 – 140.14 Mb

Chr 2:
25.08 – 25.08 Mb

PubMed search

Tubulin beta-2C chain is a protein that in humans is encoded by the TUBB2C gene.^[1]^[2]

References

^ Lewis SA, Gilmartin ME, Hall JL, Cowan NJ (Jul 1985). "Three expressed sequences within the human beta-tubulin multigene family each define a distinct isotype". J Mol Biol 182 (1): 11–20. doi:10.1016/0022-2836(85)90023-3. PMID 3999141.
^ "Entrez Gene: TUBB2C tubulin, beta 2C". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10383.

Further reading

Burgoyne RD, Cambray-Deakin MA, Lewis SA et al. (1989). "Differential distribution of beta-tubulin isotypes in cerebellum". EMBO J. 7 (8): 2311–9. PMC 457095. PMID 2461292. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=457095.
Wang D, Villasante A, Lewis SA, Cowan NJ (1987). "The mammalian beta-tubulin repertoire: hematopoietic expression of a novel, heterologous beta-tubulin isotype". J. Cell Biol. 103 (5): 1903–10. doi:10.1083/jcb.103.5.1903. PMC 2114403. PMID 3782288. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2114403.
Watts NR, Sackett DL, Ward RD et al. (2000). "HIV-1 Rev Depolymerizes Microtubules to Form Stable Bilayered Rings". J. Cell Biol. 150 (2): 349–60. doi:10.1083/jcb.150.2.349. PMC 2180222. PMID 10908577. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2180222.
Szalay J, Bruno P, Bhati R et al. (2001). "Associations of PKC isoforms with the cytoskeleton of B16F10 melanoma cells". J. Histochem. Cytochem. 49 (1): 49–66. doi:10.1177/002215540104900106. PMID 11118478.
Tarazona R, López-Lluch G, Galiani MD et al. (2001). "HLA-B2702 (77-83/83-77) peptide binds to beta-tubulin on human NK cells and blocks their cytotoxic capacity". J. Immunol. 165 (12): 6776–82. PMID 11120798.
Walss-Bass C, Xu K, David S et al. (2003). "Occurrence of nuclear beta(II)-tubulin in cultured cells". Cell Tissue Res. 308 (2): 215–23. doi:10.1007/s00441-002-0539-6. PMID 12037579.
Krebs DL, Uren RT, Metcalf D et al. (2002). "SOCS-6 Binds to Insulin Receptor Substrate 4, and Mice Lacking the SOCS-6 Gene Exhibit Mild Growth Retardation". Mol. Cell. Biol. 22 (13): 4567–78. doi:10.1128/MCB.22.13.4567-4578.2002. PMC 133908. PMID 12052866. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=133908.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Chen D, Wang M, Zhou S, Zhou Q (2004). "HIV-1 Tat targets microtubules to induce apoptosis, a process promoted by the pro-apoptotic Bcl-2 relative Bim". EMBO J. 21 (24): 6801–10. doi:10.1093/emboj/cdf683. PMC 139103. PMID 12486001. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139103.
Dozier JH, Hiser L, Davis JA et al. (2003). "β class II tubulin predominates in normal and tumor breast tissues". Breast Cancer Res. 5 (5): R157–69. doi:10.1186/bcr631. PMC 314434. PMID 12927047. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=314434.
Trinczek B, Brajenovic M, Ebneth A, Drewes G (2004). "MARK4 is a novel microtubule-associated proteins/microtubule affinity-regulating kinase that binds to the cellular microtubule network and to centrosomes". J. Biol. Chem. 279 (7): 5915–23. doi:10.1074/jbc.M304528200. PMID 14594945.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Navarro-Lérida I, Martínez Moreno M, Roncal F et al. (2004). "Proteomic identification of brain proteins that interact with dynein light chain LC8". Proteomics 4 (2): 339–46. doi:10.1002/pmic.200300528. PMID 14760703.
Campbell GR, Pasquier E, Watkins J et al. (2005). "The glutamine-rich region of the HIV-1 Tat protein is involved in T-cell apoptosis". J. Biol. Chem. 279 (46): 48197–204. doi:10.1074/jbc.M406195200. PMID 15331610.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Andersen JS, Lam YW, Leung AK et al. (2005). "Nucleolar proteome dynamics". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
de Mareuil J, Carre M, Barbier P et al. (2006). "HIV-1 Tat protein enhances Microtubule polymerization". Retrovirology 2: 5. doi:10.1186/1742-4690-2-5. PMC 549075. PMID 15691386. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=549075.
Giacca M (2006). "HIV-1 Tat, apoptosis and the mitochondria: a tubulin link?". Retrovirology 2: 7. doi:10.1186/1742-4690-2-7. PMC 549042. PMID 15698476. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=549042.
Ahmed M, Forsberg J, Bergsten P (2005). "Protein profiling of human pancreatic islets by two-dimensional gel electrophoresis and mass spectrometry". J. Proteome Res. 4 (3): 931–40. doi:10.1021/pr050024a. PMID 15952740.

PDB gallery

1ffx: TUBULIN:STATHMIN-LIKE DOMAIN COMPLEX

1ia0: KIF1A HEAD-MICROTUBULE COMPLEX STRUCTURE IN ATP-FORM

1jff: Refined structure of alpha-beta tubulin from zinc-induced sheets stabilized with taxol

1sa0: TUBULIN-COLCHICINE: STATHMIN-LIKE DOMAIN COMPLEX

1sa1: Tubulin-podophyllotoxin: stathmin-like domain complex

1tub: TUBULIN ALPHA-BETA DIMER, ELECTRON DIFFRACTION

1tvk: The binding mode of epothilone A on a,b-tubulin by electron crystallography

1z2b: Tubulin-colchicine-vinblastine: stathmin-like domain complex

2hxf: KIF1A head-microtubule complex structure in amppnp-form

2hxh: KIF1A head-microtubule complex structure in adp-form