TTF2

Transcription termination factor, RNA polymerase II

Identifiers

TTF2; HuF2

External IDs

OMIM: 604718 MGI: 1921294 HomoloGene: 37826 GeneCards: TTF2 Gene

Gene Ontology
Molecular function	• nucleotide binding • DNA binding • helicase activity • protein binding • ATP binding • ATP-dependent helicase activity • DNA-dependent ATPase activity • zinc ion binding • hydrolase activity
Cellular component	• nucleus • spliceosomal complex • cytoplasm • transcription elongation factor complex
Biological process	• transcription termination, DNA-dependent • regulation of transcription, DNA-dependent • termination of RNA polymerase II transcription • mRNA processing • RNA splicing
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 1:
117.6 – 117.65 Mb

Chr 3:
100.74 – 100.77 Mb

PubMed search

[1]

[2]

Transcription termination factor 2 is a protein that in humans is encoded by the TTF2 gene.^[1]^[2]

This gene encodes a member of the SWI2/SNF2 family of proteins, which play a critical role in altering protein-DNA interactions. The encoded protein has been shown to have dsDNA-dependent ATPase activity and RNA polymerase II termination activity. This protein interacts with cell division cycle 5-like, associates with human splicing complexes, and plays a role in pre-mRNA splicing.^[2]

Interactions

TTF2 has been shown to interact with CDC5L.^[3]

References

^ Liu M, Xie Z, Price DH (Nov 1998). "A human RNA polymerase II transcription termination factor is a SWI2/SNF2 family member". J Biol Chem 273 (40): 25541–4. doi:10.1074/jbc.273.40.25541. PMID 9748214.
^ ^a ^b "Entrez Gene: TTF2 transcription termination factor, RNA polymerase II". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8458.
^ Leonard, Deana; Ajuh Paul, Lamond Angus I, Legerski Randy J (Sep. 2003). "hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing". Biochem. Biophys. Res. Commun. (United States) 308 (4): 793–801. doi:10.1016/S0006-291X(03)01486-4. ISSN 0006-291X. PMID 12927788.

Girdham CH, Glover DM (1991). "Chromosome tangling and breakage at anaphase result from mutations in lodestar, a Drosophila gene encoding a putative nucleoside triphosphate-binding protein". Genes Dev. 5 (10): 1786–99. doi:10.1101/gad.5.10.1786. PMID 1916263.
Hara R, Selby CP, Liu M, et al. (1999). "Human transcription release factor 2 dissociates RNA polymerases I and II stalled at a cyclobutane thymine dimer". J. Biol. Chem. 274 (35): 24779–86. doi:10.1074/jbc.274.35.24779. PMID 10455150.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Leonard D, Ajuh P, Lamond AI, Legerski RJ (2003). "hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing". Biochem. Biophys. Res. Commun. 308 (4): 793–801. doi:10.1016/S0006-291X(03)01486-4. PMID 12927788.
Jiang Y, Liu M, Spencer CA, Price DH (2004). "Involvement of transcription termination factor 2 in mitotic repression of transcription elongation". Mol. Cell 14 (3): 375–85. doi:10.1016/S1097-2765(04)00234-5. PMID 15125840.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=442148.
Jiang Y, Price DH (2006). "Rescue of the TTF2 knockdown phenotype with an siRNA-resistant replacement vector". Cell Cycle 3 (9): 1151–3. PMID 15467445.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.

TTF2

Interactions

References

Further reading