TTC3

Tetratricopeptide repeat domain 3

Identifiers

TTC3; DCRR1; DKFZp686M0150; RNF105; TPRDIII

External IDs

OMIM: 602259 MGI: 1276539 HomoloGene: 2487 GeneCards: TTC3 Gene

Gene Ontology
Molecular function	• ubiquitin-protein ligase activity • protein binding • zinc ion binding • ligase activity • metal ion binding
Cellular component	• nucleus • vacuole
Biological process	• ubiquitin-dependent protein catabolic process • negative regulation of cell morphogenesis involved in differentiation • negative regulation of neuron differentiation • response to protein stimulus • protein K48-linked ubiquitination
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

n/a

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 21:
38.45 – 38.58 Mb

Chr 16:
94.59 – 94.69 Mb

PubMed search

[1]

[2]

Tetratricopeptide repeat protein 3 is a protein that in humans is encoded by the TTC3 gene.^[1]^[2]

References

^ Tsukahara F, Hattori M, Muraki T, Sakaki Y (Mar 1997). "Identification and cloning of a novel cDNA belonging to tetratricopeptide repeat gene family from Down syndrome-critical region 21q22.2". J Biochem 120 (4): 820–7. PMID 8947847.
^ "Entrez Gene: TTC3 tetratricopeptide repeat domain 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7267.

Ohira M, Ootsuyama A, Suzuki E et al. (1996). "Identification of a novel human gene containing the tetratricopeptide repeat domain from the Down syndrome region of chromosome 21". DNA Res. 3 (1): 9–16. doi:10.1093/dnares/3.1.9. PMID 8724848.
Eki T, Abe M, Naitou M et al. (1997). "Cloning and characterization of novel gene, DCRR1, expressed from Down's syndrome critical region of human chromosome 21q22.2". DNA Seq. 7 (3–4): 153–64. doi:10.3109/10425179709034031. PMID 9254009.
Dahmane N, Ghezala GA, Gosset P et al. (1998). "Transcriptional map of the 2.5-Mb CBR-ERG region of chromosome 21 involved in Down syndrome". Genomics 48 (1): 12–23. doi:10.1006/geno.1997.5146. PMID 9503011.
Rachidi M, Lopes C, Gassanova S et al. (2000). "Regional and cellular specificity of the expression of TPRD, the tetratricopeptide Down syndrome gene, during human embryonic development". Mech. Dev. 93 (1–2): 189–93. doi:10.1016/S0925-4773(00)00259-8. PMID 10781955.
Hattori M, Fujiyama A, Taylor TD et al. (2000). "The DNA sequence of human chromosome 21". Nature 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Berto G, Camera P, Fusco C et al. (2007). "The Down syndrome critical region protein TTC3 inhibits neuronal differentiation via RhoA and Citron kinase". J. Cell. Sci. 120 (Pt 11): 1859–67. doi:10.1242/jcs.000703. PMID 17488780.

TTC3

References

Further reading