Transient receptor potential cation channel, subfamily M, member 2 | |||||||||||||
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Identifiers | |||||||||||||
Symbols | TRPM2; EREG1; KNP3; LTRPC2; MGC133383; NUDT9H; NUDT9L1; TRPC7 | ||||||||||||
External IDs | OMIM: 603749 MGI: 1351901 HomoloGene: 20709 IUPHAR: TRPM2 GeneCards: TRPM2 Gene | ||||||||||||
EC number | 3.6.1.13 | ||||||||||||
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Orthologs | |||||||||||||
Species | Human | Mouse | |||||||||||
Entrez | 7226 | 28240 | |||||||||||
Ensembl | ENSG00000142185 | ENSMUSG00000009292 | |||||||||||
UniProt | O94759 | Q3UYE9 | |||||||||||
RefSeq (mRNA) | NM_003307.3 | NM_138301.2 | |||||||||||
RefSeq (protein) | NP_003298.1 | NP_612174.2 | |||||||||||
Location (UCSC) | Chr 21: 45.77 – 45.86 Mb |
Chr 10: 77.37 – 77.43 Mb |
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PubMed search | [1] | [2] |
Transient receptor potential cation channel, subfamily M, member 2, also known as TRPM2, is a protein that in humans is encoded by the TRPM2 gene.
Contents |
The TRPM2 gene is highly expressed in the brain and was implicated by both genetic linkage studies in families[1] and then by case control or trio allelic association studies in the genetic aetiology of bipolar affective disorder (Manic Depression).[2][3] The physiological role of TRPM2 is not well understood. It was shown to be involved in insulin secretion.[4] In the immune cells it mediates parts of the responses to TNF-alpha.[5] In the brain it is involved in the toxicity of amyloid beta, a protein associated with Alzheimer's disease.[6]
The protein encoded by this gene is a non-selective calcium-permeable cation channel and is part of the Transient Receptor Potential ion channel super family. The closest relative is the cold and menthol activated TRPM8 ion channel. While TRPM2 is not cold sensitive it is activated by heat.[4] The TRPM2 ion channel is activated by free intracellular ADP-ribose in synergy with free intracellular calcium.[7] ADP-Ribose is produced to by the enzyme PARP in response to oxidative stress and confers susceptibility to cell death. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.[8]
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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