TRPC5

Transient receptor potential cation channel, subfamily C, member 5
Identifiers
Symbols TRPC5; TRP5
External IDs OMIM: 300334 MGI: 109524 HomoloGene: 74915 IUPHAR: TRPC5 GeneCards: TRPC5 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 7224 22067
Ensembl ENSG00000072315 ENSMUSG00000041710
UniProt Q9UL62 Q2KHN9
RefSeq (mRNA) NM_012471.2 NM_009428.2
RefSeq (protein) NP_036603.1 NP_033454.1
Location (UCSC) Chr X:
111.02 – 111.33 Mb		 Chr X:
140.82 – 141.12 Mb
PubMed search [1] [2]

Short transient receptor potential channel 5 (TrpC5) also known as transient receptor protein 5 (TRP-5) is a protein that in humans is encoded by the TRPC5 gene.[1][2][3] TrpC5 is subtype of the TRPC family of mammalian transient receptor potential ion channels.

Contents

Function

TrpC5 is one of the seven mammalian TRPC (transient receptor potential channel) proteins. TrpC5 is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel. The protein is active alone or as a heteromultimeric assembly with TRPC1, TRPC3, and TRPC4. It also interacts with multiple proteins including calmodulin, CABP1, enkurin, Na+–H+ exchange regulatory factor (NHERF), interferon-induced GTP-binding protein (MX1), ring finger protein 24 (RNF24), and SEC14 domain and spectrin repeat-containing protein 1 (SESTD1).[1]

Activation

Homomultimeric TRPC5 and heteromultimeric TRPC5-TRPC1 channels are activated by extracellular reduced thioredoxin.[4] This channel has also been found to be involved in the action of anaesthetics such as chloroform, halothane and propofol.[5]

Interactions

TRPC5 has been shown to interact with STMN3,[6] TRPC1,[7][8] and TRPC4.[8]

See also

References

  1. ^ a b "Entrez Gene: transient receptor potential cation channel". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7224. 
  2. ^ Sossey-Alaoui K, Lyon JA, Jones L, Abidi FE, Hartung AJ, Hane B, Schwartz CE, Stevenson RE, Srivastava AK (September 1999). "Molecular cloning and characterization of TRPC5 (HTRP5), the human homologue of a mouse brain receptor-activated capacitative Ca2+ entry channel". Genomics 60 (3): 330–40. doi:10.1006/geno.1999.5924. PMID 10493832. 
  3. ^ Clapham DE, Julius D, Montell C, Schultz G (December 2005). "International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels". Pharmacol. Rev. 57 (4): 427–50. doi:10.1124/pr.57.4.6. PMID 16382100. 
  4. ^ Xu SZ, Sukumar P, Zeng F, Li J, Jairaman A, English A, Naylor J, Ciurtin C, Majeed Y, Milligan CJ, Bahnasi YM, Al-Shawaf E, Porter KE, Jiang LH, Emery P, Sivaprasadarao A, Beech DJ (January 2008). "TRPC channel activation by extracellular thioredoxin". Nature 451 (7174): 69–72. doi:10.1038/nature06414. PMC 2645077. PMID 18172497. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2645077. 
  5. ^ Bahnasi YM, Wright HM, Milligan CJ, Dedman AM, Zeng F, Hopkins PM, Bateson AN, Beech DJ (April 2008). "Modulation of TRPC5 cation channels by halothane, chloroform and propofol". Br. J. Pharmacol. 153 (7): 1505–12. doi:10.1038/sj.bjp.0707689. PMC 2437913. PMID 18204473. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2437913. 
  6. ^ Greka A, Navarro B, Oancea E, Duggan A, Clapham DE (August 2003). "TRPC5 is a regulator of hippocampal neurite length and growth cone morphology". Nat. Neurosci. 6 (8): 837–45. doi:10.1038/nn1092. PMID 12858178. 
  7. ^ Strübing C, Krapivinsky G, Krapivinsky L, Clapham DE (October 2003). "Formation of novel TRPC channels by complex subunit interactions in embryonic brain". J. Biol. Chem. 278 (40): 39014–9. doi:10.1074/jbc.M306705200. PMID 12857742. 
  8. ^ a b Hofmann T, Schaefer M, Schultz G, Gudermann T (May 2002). "Subunit composition of mammalian transient receptor potential channels in living cells". Proc. Natl. Acad. Sci. U.S.A. 99 (11): 7461–6. doi:10.1073/pnas.102596199. PMC 124253. PMID 12032305. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=124253. 

Further reading

  • Beech DJ (2007). Canonical Transient Receptor Potential 5. "Canonical transient receptor potential 5.". Handb Exp Pharmacol. Handbook of Experimental Pharmacology 179 (179): 109–23. doi:10.1007/978-3-540-34891-7_6. ISBN 978-3-540-34889-4. PMID 17217053. 
  • Beech DJ (2007). "Bipolar phospholipid sensing by TRPC5 calcium channel". Biochem. Soc. Trans. 35 (Pt 1): 101–4. doi:10.1042/BST0350101. PMID 17233612. 

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.