TRIM37

Tripartite motif containing 37
Identifiers
Symbols TRIM37; KIAA0898; MUL; POB1; TEF3
External IDs OMIM605073 MGI2153072 HomoloGene9084 GeneCards: TRIM37 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 4591 68729
Ensembl ENSG00000108395 ENSMUSG00000018548
UniProt O94972 Q5SX31
RefSeq (mRNA) NM_001005207.2 NM_197987.1
RefSeq (protein) NP_001005207.1 NP_932104.1
Location (UCSC) Chr 17:
57.06 – 57.18 Mb
Chr 11:
86.94 – 87.03 Mb
PubMed search [1] [2]

Tripartite motif-containing protein 37 is a protein that in humans is encoded by the TRIM37 gene.[1][2][3]

This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might be involved in protein-protein and/or protein-nucleic acid interactions. The gene mutations are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder that involves several tissues of mesodermal origin. Alternatively spliced transcript variants encoding the same protein have been identified.[3]

Contents

Interactions

TRIM37 has been shown to interact with PRC1.[4]

See also

References

  1. ^ Avela K, Lipsanen-Nyman M, Perheentupa J, Wallgren-Pettersson C, Marchand S, Faure S, Sistonen P, de la Chapelle A, Lehesjoki AE (May 1997). "Assignment of the mulibrey nanism gene to 17q by linkage and linkage-disequilibrium analysis". Am J Hum Genet 60 (4): 896–902. PMC 1712467. PMID 9106536. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1712467. 
  2. ^ Avela K, Lipsanen-Nyman M, Idanheimo N, Seemanova E, Rosengren S, Makela TP, Perheentupa J, Chapelle AD, Lehesjoki AE (Aug 2000). "Gene encoding a new RING-B-box-Coiled-coil protein is mutated in mulibrey nanism". Nat Genet 25 (3): 298–301. doi:10.1038/77053. PMID 10888877. 
  3. ^ a b "Entrez Gene: TRIM37 tripartite motif-containing 37". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4591. 
  4. ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct. 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 

Further reading