TRD@

T cell receptor delta locus

Identifiers

TRD@; FLJ52034; FLJ52576; FLJ53668; FLJ54555; FLJ55265; FLJ56790; TCRD; TCRDV1; TRD

External IDs

Gene Ontology

Orthologs

Species

Human

Mouse

n/a

n/a

n/a

RefSeq (mRNA)

n/a

RefSeq (protein)

n/a

Location (UCSC)

n/a

PubMed search

[1]

n/a

T cell receptor delta locus, also known as TRD@, is a human gene.^[1]

References

^ "Entrez Gene: TRD@ T cell receptor delta locus". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6964.

Chien YH, Iwashima M, Kaplan KB, et al. (1987). "A new T-cell receptor gene located within the alpha locus and expressed early in T-cell differentiation.". Nature 327 (6124): 677–82. doi:10.1038/327677a0. PMID 2439914.
Hayes SM, Shores EW, Love PE (2003). "An architectural perspective on signaling by the pre-, alphabeta and gammadelta T cell receptors.". Immunol. Rev. 191: 28–37. doi:10.1034/j.1600-065X.2003.00011.x. PMID 12614349.
Guglielmi P, Davi F, d'Auriol L, et al. (1988). "Use of a variable alpha region to create a functional T-cell receptor delta chain.". Proc. Natl. Acad. Sci. U.S.A. 85 (15): 5634–8. doi:10.1073/pnas.85.15.5634. PMC 281814. PMID 2456576. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=281814.
Hochstenbach F, Brenner MB (1989). "T-cell receptor delta-chain can substitute for alpha to form a beta delta heterodimer.". Nature 340 (6234): 562–5. doi:10.1038/340562a0. PMID 2528071.
Dyer MJ (1989). "T-cell receptor delta/alpha rearrangements in lymphoid neoplasms.". Blood 74 (3): 1073–83. PMID 2546634.
Griesinger F, Greenberg JM, Kersey JH (1989). "T cell receptor gamma and delta rearrangements in hematologic malignancies. Relationship to lymphoid differentiation.". J. Clin. Invest. 84 (2): 506–16. doi:10.1172/JCI114193. PMC 548910. PMID 2547833. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=548910.
Loh EY, Lanier LL, Turck CW, et al. (1988). "Identification and sequence of a fourth human T cell antigen receptor chain.". Nature 330 (6148): 569–72. doi:10.1038/330569a0. PMID 2825032.
Bartkowiak J, Kulczyck-Wojdala D, Blonski JZ, Robak T (2002). "Molecular diversity of gammadelta T cells in peripheral blood from patients with B-cell chronic lymphocytic leukaemia.". Neoplasma 49 (2): 86–90. PMID 12088111.
Oyoshi MK, Nagata H, Kimura N, et al. (2003). "Preferential expansion of Vgamma9-JgammaP/Vdelta2-Jdelta3 gammadelta T cells in nasal T-cell lymphoma and chronic active Epstein-Barr virus infection.". Am. J. Pathol. 162 (5): 1629–38. doi:10.1016/S0002-9440(10)64297-6. PMC 1851204. PMID 12707047. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1851204.
Krejci O, Prouzova Z, Horvath O, et al. (2003). "Cutting edge: TCR delta gene is frequently rearranged in adult B lymphocytes.". J. Immunol. 171 (2): 524–7. PMID 12847212.
van Hagen PM, Hooijkaas H, Vd Beemd MW, et al. (2003). T-γδ Receptor Restriction in Peripheral Lymphocytes of Patients with Behçet’s Disease. "T-gammadelta receptor restriction in peripheral lymphocytes of patients with Behçet's disease.". Adv. Exp. Med. Biol.. Advances in Experimental Medicine and Biology 528: 267–8. doi:10.1007/0-306-48382-3_53. ISBN 0-306-47757-2. PMID 12918704.
Szczepanski T, van der Velden VH, Hoogeveen PG, et al. (2004). "Vdelta2-Jalpha rearrangements are frequent in precursor-B-acute lymphoblastic leukemia but rare in normal lymphoid cells". Blood 103 (10): 3798–804. doi:10.1182/blood-2003-08-2952. PMID 14656882.
De Rosa SC, Andrus JP, Perfetto SP, et al. (2004). "Ontogeny of gamma delta T cells in humans". J. Immunol. 172 (3): 1637–45. PMID 14734745.
Fronková E, Krejcí O, Kalina T, et al. (2005). "Lymphoid differentiation pathways can be traced by TCR delta rearrangements". J. Immunol. 175 (4): 2495–500. PMID 16081821.
Chauhan SK, Tripathy NK, Sinha N, Nityanand S (2006). "T-cell receptor repertoire of circulating gamma delta T-cells in Takayasu's arteritis". Clin. Immunol. 118 (2–3): 243–9. doi:10.1016/j.clim.2005.10.010. PMID 16307908.
Joachims ML, Chain JL, Hooker SW, et al. (2006). "Human alpha beta and gamma delta thymocyte development: TCR gene rearrangements, intracellular TCR beta expression, and gamma delta developmental potential--differences between men and mice". J. Immunol. 176 (3): 1543–52. PMC 1592528. PMID 16424183. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1592528.
Karrman K, Andersson A, Björgvinsdóttir H, et al. (2006). "Deregulation of cyclin D2 by juxtaposition with T-cell receptor alpha/delta locus in t(12;14)(p13;q11)-positive childhood T-cell acute lymphoblastic leukemia". Eur. J. Haematol. 77 (1): 27–34. doi:10.1111/j.0902-4441.2006.t01-1-EJH2553.x. PMID 16548914.
Touvrey C, Borel E, Marche PN, et al. (2006). "Gene-specific signal joint modifications during V(D)J recombination of TCRAD locus genes in murine and human thymocytes". Immunobiology 211 (9): 741–51. doi:10.1016/j.imbio.2006.04.001. PMID 17015149.

Transmembrane receptors: Immunoglobulin superfamily immune receptors

Antibody receptor:
Fc receptor

Epsilon (ε)	FcεRI · (FcεRII is C-type lectin)

Gamma (γ)	FcγRI · FcγRII · FcγRIII · Neonatal

Alpha (α)/mu (μ)	FcαRI · Fcα/μR

Secretory	Polymeric immunoglobulin receptor

Antigen receptor

B cells

Antigen receptor	BCR

Co-receptor	stimulate: CD21/CD19/CD81 inhibit: CD22

Accessory molecules	Ig-α/Ig-β (CD79)

T cells

Ligands	MHC (MHC class I and MHC class II)

Antigen receptor	TCR: TRA@ · TRB@ · TRD@ · TRG@

Co-receptors	CD8 (with two glycoprotein chains CD8α and CD8β) · CD4

Accessory molecules	CD3 · CD3γ · CD3δ · CD3ε · ζ-chain (also called CD3ζ and TCRζ)

Cytokine receptor

see cytokine receptors

Killer-cell IG-like receptors

KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DL5B, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KIR3DS1

Leukocyte IG-like receptors

LILRA1 · LILRA2 · LILRA3 · LILRA4 · LILRA5 · LILRA6 · LILRB1 · LILRB2 · LILRB3 · LILRB4 · LILRB5 · LILRA6 · LILRA5

B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)

M: LMC

cell/phys/auag/auab/comp, igrc

imdf/ipig/hyps/tumr

proc, drug(L3/4)

TRD@

References

Further reading