TRAK2

Trafficking protein, kinesin binding 2

Identifiers

TRAK2; ALS2CR3; CALS-C; GRIF-1; GRIF1; KIAA0549; OIP98

External IDs

OMIM: 607334 MGI: 1918077 HomoloGene: 22861 GeneCards: TRAK2 Gene

Gene Ontology
Molecular function	• receptor binding • protein binding • enzyme binding • GABA receptor binding
Cellular component	• nucleus • cytoplasm • early endosome • plasma membrane
Biological process	• regulation of transcription from RNA polymerase II promoter • protein O-linked glycosylation • protein targeting • transport
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

n/a

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 2:
202.24 – 202.32 Mb

Chr 1:
58.96 – 59.03 Mb

PubMed search

[1]

[2]

Trafficking kinesin-binding protein 2 is a protein that in humans is encoded by the TRAK2 gene.^[1]^[2]^[3]

Interactions

TRAK2 has been shown to interact with Kir2.1^[4] and GABRB2.^[5]

References

^ Hadano S, Yanagisawa Y, Skaug J, Fichter K, Nasir J, Martindale D, Koop BF, Scherer SW, Nicholson DW, Rouleau GA, Ikeda J, Hayden MR (Feb 2001). "Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: candidate genes for ALS2". Genomics 71 (2): 200–13. doi:10.1006/geno.2000.6392. PMID 11161814.
^ Gilbert SL, Zhang L, Forster ML, Anderson JR, Iwase T, Soliven B, Donahue LR, Sweet HO, Bronson RT, Davisson MT, Wollmann RL, Lahn BT (Jan 2006). "Trak1 mutation disrupts GABA(A) receptor homeostasis in hypertonic mice". Nat Genet 38 (2): 245–50. doi:10.1038/ng1715. PMID 16380713.
^ "Entrez Gene: TRAK2 trafficking protein, kinesin binding 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=66008.
^ Grishin, Anatoly; Li Hui, Levitan Edwin S, Zaks-Makhina Elena (Oct. 2006). "Identification of gamma-aminobutyric acid receptor-interacting factor 1 (TRAK2) as a trafficking factor for the K+ channel Kir2.1". J. Biol. Chem. (United States) 281 (40): 30104–11. doi:10.1074/jbc.M602439200. ISSN 0021-9258. PMID 16895905.
^ Beck, Mike; Brickley Kieran, Wilkinson Helen L, Sharma Seema, Smith Miriam, Chazot Paul L, Pollard Simon, Stephenson F Anne (Aug. 2002). "Identification, molecular cloning, and characterization of a novel GABAA receptor-associated protein, GRIF-1". J. Biol. Chem. (United States) 277 (33): 30079–90. doi:10.1074/jbc.M200438200. ISSN 0021-9258. PMID 12034717.

Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.
Machado RD, Pauciulo MW, Fretwell N, et al. (2001). "A physical and transcript map based upon refinement of the critical interval for PPH1, a gene for familial primary pulmonary hypertension. The International PPH Consortium.". Genomics 68 (2): 220–8. doi:10.1006/geno.2000.6291. PMID 10964520.
Beck M, Brickley K, Wilkinson HL, et al. (2002). "Identification, molecular cloning, and characterization of a novel GABAA receptor-associated protein, GRIF-1.". J. Biol. Chem. 277 (33): 30079–90. doi:10.1074/jbc.M200438200. PMID 12034717.
Iyer SP, Akimoto Y, Hart GW (2003). "Identification and cloning of a novel family of coiled-coil domain proteins that interact with O-GlcNAc transferase.". J. Biol. Chem. 278 (7): 5399–409. doi:10.1074/jbc.M209384200. PMID 12435728.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Brickley K, Smith MJ, Beck M, Stephenson FA (2005). "GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins: association in vivo and in vitro with kinesin.". J. Biol. Chem. 280 (15): 14723–32. doi:10.1074/jbc.M409095200. PMID 15644324.
Fransson S, Ruusala A, Aspenström P (2006). "The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking.". Biochem. Biophys. Res. Commun. 344 (2): 500–10. doi:10.1016/j.bbrc.2006.03.163. PMID 16630562.
Smith MJ, Pozo K, Brickley K, Stephenson FA (2006). "Mapping the GRIF-1 binding domain of the kinesin, KIF5C, substantiates a role for GRIF-1 as an adaptor protein in the anterograde trafficking of cargoes.". J. Biol. Chem. 281 (37): 27216–28. doi:10.1074/jbc.M600522200. PMID 16835241.
Grishin A, Li H, Levitan ES, Zaks-Makhina E (2006). "Identification of gamma-aminobutyric acid receptor-interacting factor 1 (TRAK2) as a trafficking factor for the K+ channel Kir2.1.". J. Biol. Chem. 281 (40): 30104–11. doi:10.1074/jbc.M602439200. PMID 16895905.

TRAK2

Interactions

References

Further reading