TRAF5

TNF receptor-associated factor 5

Identifiers

TRAF5; MGC:39780; RNF84

External IDs

OMIM: 602356 HomoloGene: 27079 GeneCards: TRAF5 Gene

Gene Ontology
Molecular function	• ubiquitin-protein ligase activity • signal transducer activity • protein binding • zinc ion binding • metal ion binding
Cellular component	• cytoplasm • centrosome • internal side of plasma membrane • CD40 receptor complex
Biological process	• signal transduction • positive regulation of cell proliferation • regulation of apoptosis • positive regulation of I-kappaB kinase/NF-kappaB cascade • positive regulation of sequence-specific DNA binding transcription factor activity • positive regulation of NF-kappaB transcription factor activity
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

n/a

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 1:
211.5 – 211.55 Mb

Chr 1:
193.82 – 193.92 Mb

PubMed search

[1]

[2]

TNF receptor-associated factor 5 is a protein that in humans is encoded by the TRAF5 gene.^[1]

The scaffold protein encoded by this gene is a member of the tumor necrosis factor receptor-associated factor (TRAF) protein family and contains a meprin and TRAF homology (MATH) domain, a RING-type zinc finger, and two TRAF-type zinc fingers. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein is one of the components of a multiple protein complex which binds to tumor necrosis factor (TNF) receptor cytoplasmic domains and mediates TNF-induced activation. Alternate transcriptional splice variants have been characterized.^[2]

Interactions

TRAF5 has been shown to interact with ASK1,^[3]^[4] TNFRSF13B,^[5] CD134,^[6] CD30,^[7] CD40,^[8]^[9] RANK^[10]^[11]^[12] and TNFRSF14.^[13]^[14]

References

^ Tang XX, Pleasure DE, Ikegaki N (May 1997). "cDNA cloning, chromosomal localization, and expression pattern of EPLG8, a new member of the EPLG gene family encoding ligands of EPH-related protein-tyrosine kinase receptors". Genomics 41 (1): 17–24. doi:10.1006/geno.1997.4615. PMID 9126477.
^ "Entrez Gene: TRAF5 TNF receptor-associated factor 5". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7188.
^ Nishitoh, H; Saitoh M, Mochida Y, Takeda K, Nakano H, Rothe M, Miyazono K, Ichijo H (Sep. 1998). "ASK1 is essential for JNK/SAPK activation by TRAF2". Mol. Cell (UNITED STATES) 2 (3): 389–95. doi:10.1016/S1097-2765(00)80283-X. ISSN 1097-2765. PMID 9774977.
^ Hoeflich, K P; Yeh W C, Yao Z, Mak T W, Woodgett J R (Oct. 1999). "Mediation of TNF receptor-associated factor effector functions by apoptosis signal-regulating kinase-1 (ASK1)". Oncogene (ENGLAND) 18 (42): 5814–20. doi:10.1038/sj.onc.1202975. ISSN 0950-9232. PMID 10523862.
^ Xia, X Z; Treanor J, Senaldi G, Khare S D, Boone T, Kelley M, Theill L E, Colombero A, Solovyev I, Lee F, McCabe S, Elliott R, Miner K, Hawkins N, Guo J, Stolina M, Yu G, Wang J, Delaney J, Meng S Y, Boyle W J, Hsu H (Jul. 2000). "Taci Is a Traf-Interacting Receptor for Tall-1, a Tumor Necrosis Factor Family Member Involved in B Cell Regulation". J. Exp. Med. (UNITED STATES) 192 (1): 137–43. doi:10.1084/jem.192.1.137. ISSN 0022-1007. PMC 1887716. PMID 10880535. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1887716.
^ Kawamata, S; Hori T, Imura A, Takaori-Kondo A, Uchiyama T (Mar. 1998). "Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5-mediated NF-kappaB activation". J. Biol. Chem. (UNITED STATES) 273 (10): 5808–14. doi:10.1074/jbc.273.10.5808. ISSN 0021-9258. PMID 9488716.
^ Aizawa, S; Nakano H, Ishida T, Horie R, Nagai M, Ito K, Yagita H, Okumura K, Inoue J, Watanabe T (Jan. 1997). "Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NFkappaB activation". J. Biol. Chem. (UNITED STATES) 272 (4): 2042–5. doi:10.1074/jbc.272.4.2042. ISSN 0021-9258. PMID 8999898.
^ Tsukamoto, N; Kobayashi N, Azuma S, Yamamoto T, Inoue J (Feb. 1999). "Two differently regulated nuclear factor κB activation pathways triggered by the cytoplasmic tail of CD40". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (4): 1234–9. doi:10.1073/pnas.96.4.1234. ISSN 0027-8424. PMC 15446. PMID 9990007. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=15446.
^ Ishida, T K; Tojo T, Aoki T, Kobayashi N, Ohishi T, Watanabe T, Yamamoto T, Inoue J (Sep. 1996). "TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 93 (18): 9437–42. doi:10.1073/pnas.93.18.9437. ISSN 0027-8424. PMC 38446. PMID 8790348. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=38446.
^ Darnay, B G; Haridas V, Ni J, Moore P A, Aggarwal B B (Aug. 1998). "Characterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N-terminal kinase". J. Biol. Chem. (UNITED STATES) 273 (32): 20551–5. doi:10.1074/jbc.273.32.20551. ISSN 0021-9258. PMID 9685412.
^ Darnay, B G; Ni J, Moore P A, Aggarwal B B (Mar. 1999). "Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif". J. Biol. Chem. (UNITED STATES) 274 (12): 7724–31. doi:10.1074/jbc.274.12.7724. ISSN 0021-9258. PMID 10075662.
^ Galibert, L; Tometsko M E, Anderson D M, Cosman D, Dougall W C (Dec. 1998). "The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily". J. Biol. Chem. (UNITED STATES) 273 (51): 34120–7. doi:10.1074/jbc.273.51.34120. ISSN 0021-9258. PMID 9852070.
^ Hsu, H; Solovyev I, Colombero A, Elliott R, Kelley M, Boyle W J (May. 1997). "ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5". J. Biol. Chem. (UNITED STATES) 272 (21): 13471–4. doi:10.1074/jbc.272.21.13471. ISSN 0021-9258. PMID 9153189.
^ Marsters, S A; Ayres T M, Skubatch M, Gray C L, Rothe M, Ashkenazi A (May. 1997). "Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1". J. Biol. Chem. (UNITED STATES) 272 (22): 14029–32. doi:10.1074/jbc.272.22.14029. ISSN 0021-9258. PMID 9162022.

Wajant H, Henkler F, Scheurich P (2001). "The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators". Cell. Signal. 13 (6): 389–400. doi:10.1016/S0898-6568(01)00160-7. PMID 11384837.
Bradley JR, Pober JS (2001). "Tumor necrosis factor receptor-associated factors (TRAFs)". Oncogene 20 (44): 6482–91. doi:10.1038/sj.onc.1204788. PMID 11607847.
Nakano H, Oshima H, Chung W, et al. (1996). "TRAF5, an activator of NF-kappaB and putative signal transducer for the lymphotoxin-beta receptor". J. Biol. Chem. 271 (25): 14661–4. doi:10.1074/jbc.271.25.14661. PMID 8663299.
Ishida TK, Tojo T, Aoki T, et al. (1996). "TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling". Proc. Natl. Acad. Sci. U.S.A. 93 (18): 9437–42. doi:10.1073/pnas.93.18.9437. PMC 38446. PMID 8790348. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=38446.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Ansieau S, Scheffrahn I, Mosialos G, et al. (1997). "Tumor necrosis factor receptor-associated factor (TRAF)-1, TRAF-2, and TRAF-3 interact in vivo with the CD30 cytoplasmic domain; TRAF-2 mediates CD30-induced nuclear factor kappa B activation". Proc. Natl. Acad. Sci. U.S.A. 93 (24): 14053–8. doi:10.1073/pnas.93.24.14053. PMC 19493. PMID 8943059. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=19493.
Aizawa S, Nakano H, Ishida T, et al. (1997). "Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NFkappaB activation". J. Biol. Chem. 272 (4): 2042–5. doi:10.1074/jbc.272.4.2042. PMID 8999898.
Hsu H, Solovyev I, Colombero A, et al. (1997). "ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5". J. Biol. Chem. 272 (21): 13471–4. doi:10.1074/jbc.272.21.13471. PMID 9153189.
Marsters SA, Ayres TM, Skubatch M, et al. (1997). "Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1". J. Biol. Chem. 272 (22): 14029–32. doi:10.1074/jbc.272.22.14029. PMID 9162022.
Nakano H, Shindo M, Yamada K, et al. (1997). "Human TNF receptor-associated factor 5 (TRAF5): cDNA cloning, expression and assignment of the TRAF5 gene to chromosome 1q32". Genomics 42 (1): 26–32. doi:10.1006/geno.1997.4697. PMID 9177772.
Song HY, Régnier CH, Kirschning CJ, et al. (1997). "Tumor necrosis factor (TNF)-mediated kinase cascades: Bifurcation of Nuclear Factor-κB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2". Proc. Natl. Acad. Sci. U.S.A. 94 (18): 9792–6. doi:10.1073/pnas.94.18.9792. PMC 23270. PMID 9275204. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=23270.
Kawamata S, Hori T, Imura A, et al. (1998). "Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5-mediated NF-kappaB activation". J. Biol. Chem. 273 (10): 5808–14. doi:10.1074/jbc.273.10.5808. PMID 9488716.
Mizushima S, Fujita M, Ishida T, et al. (1998). "Cloning and characterization of a cDNA encoding the human homolog of tumor necrosis factor receptor-associated factor 5 (TRAF5)". Gene 207 (2): 135–40. doi:10.1016/S0378-1119(97)00616-1. PMID 9511754.
Akiba H, Nakano H, Nishinaka S, et al. (1998). "CD27, a member of the tumor necrosis factor receptor superfamily, activates NF-kappaB and stress-activated protein kinase/c-Jun N-terminal kinase via TRAF2, TRAF5, and NF-kappaB-inducing kinase". J. Biol. Chem. 273 (21): 13353–8. doi:10.1074/jbc.273.21.13353. PMID 9582383.
McCarthy JV, Ni J, Dixit VM (1998). "RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase". J. Biol. Chem. 273 (27): 16968–75. doi:10.1074/jbc.273.27.16968. PMID 9642260.
Pullen SS, Miller HG, Everdeen DS, et al. (1998). "CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization". Biochemistry 37 (34): 11836–45. doi:10.1021/bi981067q. PMID 9718306.
Wong BR, Josien R, Lee SY, et al. (1998). "The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor". J. Biol. Chem. 273 (43): 28355–9. doi:10.1074/jbc.273.43.28355. PMID 9774460.
Nishitoh H, Saitoh M, Mochida Y, et al. (1998). "ASK1 is essential for JNK/SAPK activation by TRAF2". Mol. Cell 2 (3): 389–95. doi:10.1016/S1097-2765(00)80283-X. PMID 9774977.
Tsukamoto N, Kobayashi N, Azuma S, et al. (1999). "Two differently regulated nuclear factor κB activation pathways triggered by the cytoplasmic tail of CD40". Proc. Natl. Acad. Sci. U.S.A. 96 (4): 1234–9. doi:10.1073/pnas.96.4.1234. PMC 15446. PMID 9990007. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=15446.

Cell signaling: carrier proteins: signal transducing adaptor proteins

JAK-STAT	see JAK-STAT signaling pathway

Growth factor receptor-bound protein	GRB2 · GRB7 · GRB10

Other	14-3-3 (YWHAE, YWHAZ) · Caveolin · Cortactin · Death-inducing signaling complex · Paxillin · Myd88 · SMAD · TRAF (TRAF1, TRAF2, TRAF3, TRAF4, TRAF5, TRAF6) · BIN1 · SH3BP2 · LDB3 CHM · CHML

B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)

TRAF5

Interactions

References

Further reading