TRADD
Tumor necrosis factor receptor type 1-associated DEATH domain protein is a protein that in humans is encoded by the TRADD gene.[1][2]
TRADD is an adaptor protein.
Function
The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway.[2]
Interactions
TRADD has been shown to interact with STAT1,[3] TNFRSF1A,[4][5][6][7][8][9][10] FADD,[11][8][12] TNFRSF25,[13] TRAF2,[14][15][16][17][18][8][19] Keratin 18[20] and RIPK1.[7]
See also
References
- ^ Hsu H, Xiong J, Goeddel DV (Jun 1995). "The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation". Cell 81 (4): 495–504. doi:10.1016/0092-8674(95)90070-5. PMID 7758105.
- ^ a b "Entrez Gene: TRADD TNFRSF1A-associated via death domain". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8717.
- ^ Wang, Y; Wu T R, Cai S, Welte T, Chin Y E (Jul. 2000). "Stat1 as a Component of Tumor Necrosis Factor Alpha Receptor 1-TRADD Signaling Complex To Inhibit NF-κB Activation". Mol. Cell. Biol. (UNITED STATES) 20 (13): 4505–12. doi:10.1128/MCB.20.13.4505-4512.2000. ISSN 0270-7306. PMC 85828. PMID 10848577. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=85828.
- ^ Jiang, Y; Woronicz J D, Liu W, Goeddel D V (Jan. 1999). "Prevention of constitutive TNF receptor 1 signaling by silencer of death domains". Science (UNITED STATES) 283 (5401): 543–6. doi:10.1126/science.283.5401.543. ISSN 0036-8075. PMID 9915703.
- ^ Schütze, S; Machleidt T, Adam D, Schwandner R, Wiegmann K, Kruse M L, Heinrich M, Wickel M, Krönke M (Apr. 1999). "Inhibition of receptor internalization by monodansylcadaverine selectively blocks p55 tumor necrosis factor receptor death domain signaling". J. Biol. Chem. (UNITED STATES) 274 (15): 10203–12. doi:10.1074/jbc.274.15.10203. ISSN 0021-9258. PMID 10187805.
- ^ Pan, G; O'Rourke K, Chinnaiyan A M, Gentz R, Ebner R, Ni J, Dixit V M (Apr. 1997). "The receptor for the cytotoxic ligand TRAIL". Science (UNITED STATES) 276 (5309): 111–3. doi:10.1126/science.276.5309.111. ISSN 0036-8075. PMID 9082980.
- ^ a b Hsu, H; Huang J, Shu H B, Baichwal V, Goeddel D V (Apr. 1996). "TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex". Immunity (UNITED STATES) 4 (4): 387–96. doi:10.1016/S1074-7613(00)80252-6. ISSN 1074-7613. PMID 8612133.
- ^ a b c Hsu, H; Shu H B, Pan M G, Goeddel D V (Jan. 1996). "TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways". Cell (UNITED STATES) 84 (2): 299–308. doi:10.1016/S0092-8674(00)80984-8. ISSN 0092-8674. PMID 8565075.
- ^ Shu, H B; Takeuchi M, Goeddel D V (Nov. 1996). "The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 93 (24): 13973–8. doi:10.1073/pnas.93.24.13973. ISSN 0027-8424. PMC 19479. PMID 8943045. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=19479.
- ^ Blankenship, John W; Varfolomeev Eugene, Goncharov Tatiana, Fedorova Anna V, Kirkpatrick Donald S, Izrael-Tomasevic Anita, Phu Lilian, Arnott David, Aghajan Mariam, Zobel Kerry, Bazan J Fernando, Fairbrother Wayne J, Deshayes Kurt, Vucic Domagoj (Jan. 2009). "Ubiquitin binding modulates IAP antagonist-stimulated proteasomal degradation of c-IAP1 and c-IAP2(1)". Biochem. J. (England) 417 (1): 149–60. doi:10.1042/BJ20081885. PMID 18939944.
- ^ Henshall, David C; Araki Tomohiro, Schindler Clara K, Shinoda Sachiko, Lan Jing-Quan, Simon Roger P (Sep. 2003). "Expression of death-associated protein kinase and recruitment to the tumor necrosis factor signaling pathway following brief seizures". J. Neurochem. (England) 86 (5): 1260–70. doi:10.1046/j.1471-4159.2003.01934.x. ISSN 0022-3042. PMID 12911633.
- ^ Thomas, Lance R; Stillman David J, Thorburn Andrew (Sep. 2002). "Regulation of Fas-associated death domain interactions by the death effector domain identified by a modified reverse two-hybrid screen". J. Biol. Chem. (United States) 277 (37): 34343–8. doi:10.1074/jbc.M204169200. ISSN 0021-9258. PMID 12107169.
- ^ Kitson, J; Raven T, Jiang Y P, Goeddel D V, Giles K M, Pun K T, Grinham C J, Brown R, Farrow S N (Nov. 1996). "A death-domain-containing receptor that mediates apoptosis". Nature (ENGLAND) 384 (6607): 372–5. doi:10.1038/384372a0. ISSN 0028-0836. PMID 8934525.
- ^ Bouwmeester, Tewis; Bauch Angela, Ruffner Heinz, Angrand Pierre-Olivier, Bergamini Giovanna, Croughton Karen, Cruciat Cristina, Eberhard Dirk, Gagneur Julien, Ghidelli Sonja, Hopf Carsten, Huhse Bettina, Mangano Raffaella, Michon Anne-Marie, Schirle Markus, Schlegl Judith, Schwab Markus, Stein Martin A, Bauer Andreas, Casari Georg, Drewes Gerard, Gavin Anne-Claude, Jackson David B, Joberty Gerard, Neubauer Gitte, Rick Jens, Kuster Bernhard, Superti-Furga Giulio (Feb. 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. (England) 6 (2): 97–105. doi:10.1038/ncb1086. ISSN 1465-7392. PMID 14743216.
- ^ Takeuchi, M; Rothe M, Goeddel D V (Aug. 1996). "Anatomy of TRAF2. Distinct domains for nuclear factor-kappaB activation and association with tumor necrosis factor signaling proteins". J. Biol. Chem. (UNITED STATES) 271 (33): 19935–42. doi:10.1074/jbc.271.33.19935. ISSN 0021-9258. PMID 8702708.
- ^ Park, Y C; Ye H, Hsia C, Segal D, Rich R L, Liou H C, Myszka D G, Wu H (Jun. 2000). "A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction". Cell (UNITED STATES) 101 (7): 777–87. doi:10.1016/S0092-8674(00)80889-2. ISSN 0092-8674. PMID 10892748.
- ^ Tsao, D H; McDonagh T, Telliez J B, Hsu S, Malakian K, Xu G Y, Lin L L (Jun. 2000). "Solution structure of N-TRADD and characterization of the interaction of N-TRADD and C-TRAF2, a key step in the TNFR1 signaling pathway". Mol. Cell (UNITED STATES) 5 (6): 1051–7. doi:10.1016/S1097-2765(00)80270-1. ISSN 1097-2765. PMID 10911999.
- ^ Tada, K; Okazaki T, Sakon S, Kobarai T, Kurosawa K, Yamaoka S, Hashimoto H, Mak T W, Yagita H, Okumura K, Yeh W C, Nakano H (Sep. 2001). "Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-kappa B activation and protection from cell death". J. Biol. Chem. (United States) 276 (39): 36530–4. doi:10.1074/jbc.M104837200. ISSN 0021-9258. PMID 11479302.
- ^ Malinin, N L; Boldin M P, Kovalenko A V, Wallach D (Feb. 1997). "MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1". Nature (ENGLAND) 385 (6616): 540–4. doi:10.1038/385540a0. ISSN 0028-0836. PMID 9020361.
- ^ Inada, H; Izawa I, Nishizawa M, Fujita E, Kiyono T, Takahashi T, Momoi T, Inagaki M (Oct. 2001). "Keratin attenuates tumor necrosis factor–induced cytotoxicity through association with TRADD". J. Cell Biol. (United States) 155 (3): 415–26. doi:10.1083/jcb.200103078. ISSN 0021-9525. PMC 2150850. PMID 11684708. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2150850.
Further reading
- Baker SJ, Reddy EP (1999). "Modulation of life and death by the TNF receptor superfamily". Oncogene 17 (25): 3261–70. doi:10.1038/sj.onc.1202568. PMID 9916988.
- Hsu H, Shu HB, Pan MG, Goeddel DV (1996). "TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways". Cell 84 (2): 299–308. doi:10.1016/S0092-8674(00)80984-8. PMID 8565075.
- Hsu H, Huang J, Shu HB, et al. (1996). "TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex". Immunity 4 (4): 387–96. doi:10.1016/S1074-7613(00)80252-6. PMID 8612133.
- Boldin MP, Goncharov TM, Goltsev YV, Wallach D (1996). "Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death". Cell 85 (6): 803–15. doi:10.1016/S0092-8674(00)81265-9. PMID 8681376.
- Takeuchi M, Rothe M, Goeddel DV (1996). "Anatomy of TRAF2. Distinct domains for nuclear factor-kappaB activation and association with tumor necrosis factor signaling proteins". J. Biol. Chem. 271 (33): 19935–42. doi:10.1074/jbc.271.33.19935. PMID 8702708.
- Kitson J, Raven T, Jiang YP, et al. (1996). "A death-domain-containing receptor that mediates apoptosis". Nature 384 (6607): 372–5. doi:10.1038/384372a0. PMID 8934525.
- Shu HB, Takeuchi M, Goeddel DV (1997). "The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex". Proc. Natl. Acad. Sci. U.S.A. 93 (24): 13973–8. doi:10.1073/pnas.93.24.13973. PMC 19479. PMID 8943045. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=19479.
- Izumi KM, Kieff ED (1997). "The Epstein–Barr virus oncogene product latent membrane protein 1 engages the tumor necrosis factor receptor-associated death domain protein to mediate B lymphocyte growth transformation and activate NF-κB". Proc. Natl. Acad. Sci. U.S.A. 94 (23): 12592–7. doi:10.1073/pnas.94.23.12592. PMC 25049. PMID 9356494. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=25049.
- Wajant H, Johannes FJ, Haas E, et al. (1998). "Dominant-negative FADD inhibits TNFR60-, Fas/Apo1- and TRAIL-R/Apo2-mediated cell death but not gene induction". Curr. Biol. 8 (2): 113–6. doi:10.1016/S0960-9822(98)70042-9. PMID 9427646.
- Chaudhary PM, Eby M, Jasmin A, et al. (1998). "Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway". Immunity 7 (6): 821–30. doi:10.1016/S1074-7613(00)80400-8. PMID 9430227.
- Pan G, Bauer JH, Haridas V, et al. (1998). "Identification and functional characterization of DR6, a novel death domain-containing TNF receptor". FEBS Lett. 431 (3): 351–6. doi:10.1016/S0014-5793(98)00791-1. PMID 9714541.
- Jones SJ, Ledgerwood EC, Prins JB, et al. (1999). "TNF recruits TRADD to the plasma membrane but not the trans-Golgi network, the principal subcellular location of TNF-R1". J. Immunol. 162 (2): 1042–8. PMID 9916731.
- Schütze S, Machleidt T, Adam D, et al. (1999). "Inhibition of receptor internalization by monodansylcadaverine selectively blocks p55 tumor necrosis factor receptor death domain signaling". J. Biol. Chem. 274 (15): 10203–12. doi:10.1074/jbc.274.15.10203. PMID 10187805.
- Sanz L, Sanchez P, Lallena MJ, et al. (1999). "The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation". EMBO J. 18 (11): 3044–53. doi:10.1093/emboj/18.11.3044. PMC 1171386. PMID 10356400. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1171386.
- Costanzo A, Guiet C, Vito P (1999). "c-E10 is a caspase-recruiting domain-containing protein that interacts with components of death receptors signaling pathway and activates nuclear factor-kappaB". J. Biol. Chem. 274 (29): 20127–32. doi:10.1074/jbc.274.29.20127. PMID 10400625.
- Wang Y, Wu TR, Cai S, et al. (2000). "Stat1 as a Component of Tumor Necrosis Factor Alpha Receptor 1-TRADD Signaling Complex To Inhibit NF-κB Activation". Mol. Cell. Biol. 20 (13): 4505–12. doi:10.1128/MCB.20.13.4505-4512.2000. PMC 85828. PMID 10848577. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=85828.
- Park YC, Ye H, Hsia C, et al. (2000). "A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction". Cell 101 (7): 777–87. doi:10.1016/S0092-8674(00)80889-2. PMID 10892748.
- Tsao DH, McDonagh T, Telliez JB, et al. (2000). "Solution structure of N-TRADD and characterization of the interaction of N-TRADD and C-TRAF2, a key step in the TNFR1 signaling pathway". Mol. Cell 5 (6): 1051–7. doi:10.1016/S1097-2765(00)80270-1. PMID 10911999.
External links
PDB gallery
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1f2h: SOLUTION STRUCTURE OF THE N-TERMINAL DOMAIN OF THE TNFR1 ASSOCIATED PROTEIN, TRADD.
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1f3v: CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN THE N-TERMINAL DOMAIN OF TRADD AND THE TRAF DOMAIN OF TRAF2
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Fas path |
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TNF path |
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Other |
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B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
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