TOMM70A

Translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)

Identifiers

External IDs

OMIM: 606081 MGI: 106295 HomoloGene: 40112 GeneCards: TOMM70A Gene

Gene Ontology
Molecular function	• protein binding • protein transmembrane transporter activity
Cellular component	• mitochondrion • mitochondrial outer membrane translocase complex • membrane • integral to membrane
Biological process	• protein targeting to mitochondrion
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 3:
100.08 – 100.12 Mb

Chr 16:
57.12 – 57.16 Mb

PubMed search

[1]

[2]

Mitochondrial import receptor subunit TOM70 is a protein that in humans is encoded by the TOMM70A gene.^[1]^[2]

The translocase of outer mitochondrial membrane (TOM) complex is a multisubunit complex involved in the recognition, unfolding, and translocation of preproteins into the mitochondria. See TIM17A (MIM 605057).[supplied by OMIM]^[2]

References

^ Alvarez-Dolado M, Gonzalez-Moreno M, Valencia A, Zenke M, Bernal J, Munoz A (Dec 1999). "Identification of a mammalian homologue of the fungal Tom70 mitochondrial precursor protein import receptor as a thyroid hormone-regulated gene in specific brain regions". J Neurochem 73 (6): 2240–9. doi:10.1046/j.1471-4159.1999.0732240.x. PMID 10582581.
^ ^a ^b "Entrez Gene: TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9868.

Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
Edmonson AM, Mayfield DK, Vervoort V, et al. (2002). "Characterization of a human import component of the mitochondrial outer membrane, TOMM70A". Cell Commun. Adhes. 9 (1): 15–27. doi:10.1080/15419060212186. PMID 12200962.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Young JC, Hoogenraad NJ, Hartl FU (2003). "Molecular chaperones Hsp90 and Hsp70 deliver preproteins to the mitochondrial import receptor Tom70". Cell 112 (1): 41–50. doi:10.1016/S0092-8674(02)01250-3. PMID 12526792.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Humphries AD, Streimann IC, Stojanovski D, et al. (2005). "Dissection of the mitochondrial import and assembly pathway for human Tom40". J. Biol. Chem. 280 (12): 11535–43. doi:10.1074/jbc.M413816200. PMID 15644312.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Chou CH, Lee RS, Yang-Yen HF (2006). "An Internal EELD Domain Facilitates Mitochondrial Targeting of Mcl-1 via a Tom70-dependent Pathway". Mol. Biol. Cell 17 (9): 3952–63. doi:10.1091/mbc.E06-04-0319. PMC 1593170. PMID 16822835. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1593170.
Fan AC, Bhangoo MK, Young JC (2006). "Hsp90 functions in the targeting and outer membrane translocation steps of Tom70-mediated mitochondrial import". J. Biol. Chem. 281 (44): 33313–24. doi:10.1074/jbc.M605250200. PMID 16968702.

TOMM70A

References

Further reading