TNKS2

Tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2

Rendering based on PDB 3KR7.

Available structures
PDB	3KR7, 3KR8, 3MHJ, 3MHK, 3P0N, 3P0P, 3P0Q

Identifiers

TNKS2; PARP-5b; PARP-5c; PARP5B; PARP5C; TANK2; TNKL; pART6

External IDs

OMIM: 607128 MGI: 1921743 HomoloGene: 11890 GeneCards: TNKS2 Gene

Gene Ontology
Molecular function	• NAD+ ADP-ribosyltransferase activity • protein binding • transferase activity, transferring glycosyl groups
Cellular component	• Golgi membrane • pericentriolar material • nuclear chromosome, telomeric region • nucleus • nuclear envelope • chromosome • cytoplasm • microsome • Golgi apparatus • membrane • perinuclear region of cytoplasm
Biological process	• protein polyubiquitination • protein ADP-ribosylation • Wnt receptor signaling pathway • positive regulation of telomere maintenance via telomerase • protein localization to chromosome, telomeric region • protein auto-ADP-ribosylation • positive regulation of canonical Wnt receptor signaling pathway
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

ENSG00000107854

ENSMUSG00000024811

n/a

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 10:
93.56 – 93.63 Mb

Chr 19:
36.91 – 36.97 Mb

PubMed search

Tankyrase-2 is an enzyme that in humans is encoded by the TNKS2 gene.^[1]

Interactions

TNKS2 has been shown to interact with GRB14,^[2] TERF1^[3]^[4]^[5] and Cystinyl aminopeptidase.^[6]^[4]^[5]

References

^ "Entrez Gene: TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=80351.
^ Lyons, R J; Deane R, Lynch D K, Ye Z S, Sanderson G M, Eyre H J, Sutherland G R, Daly R J (May. 2001). "Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14". J. Biol. Chem. (United States) 276 (20): 17172–80. doi:10.1074/jbc.M009756200. ISSN 0021-9258. PMID 11278563.
^ Cook, Brandoch D; Dynek Jasmin N, Chang William, Shostak Grigoriy, Smith Susan (Jan. 2002). "Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres". Mol. Cell. Biol. (United States) 22 (1): 332–42. doi:10.1128/MCB.22.1.332-342.2002. ISSN 0270-7306. PMC 134233. PMID 11739745. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=134233.
^ ^a ^b Chi, N W; Lodish H F (Dec. 2000). "Tankyrase is a golgi-associated mitogen-activated protein kinase substrate that interacts with IRAP in GLUT4 vesicles". J. Biol. Chem. (UNITED STATES) 275 (49): 38437–44. doi:10.1074/jbc.M007635200. ISSN 0021-9258. PMID 10988299.
^ ^a ^b Sbodio, Juan I; Lodish Harvey F, Chi Nai-Wen (Feb. 2002). "Tankyrase-2 oligomerizes with tankyrase-1 and binds to both TRF1 (telomere-repeat-binding factor 1) and IRAP (insulin-responsive aminopeptidase)". Biochem. J. (England) 361 (Pt 3): 451–9. doi:10.1042/0264-6021:3610451. ISSN 0264-6021. PMC 1222327. PMID 11802774. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1222327.
^ Sbodio, Juan I; Chi Nai-Wen (Aug. 2002). "Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner". J. Biol. Chem. (United States) 277 (35): 31887–92. doi:10.1074/jbc.M203916200. ISSN 0021-9258. PMID 12080061.

Further reading

Monz D, Munnia A, Comtesse N, et al. (2001). "Novel tankyrase-related gene detected with meningioma-specific sera.". Clin. Cancer Res. 7 (1): 113–9. PMID 11205898.
Lyons RJ, Deane R, Lynch DK, et al. (2001). "Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14.". J. Biol. Chem. 276 (20): 17172–80. doi:10.1074/jbc.M009756200. PMID 11278563.
Kuimov AN, Kuprash DV, Petrov VN, et al. (2001). "Cloning and characterization of TNKL, a member of tankyrase gene family.". Genes Immun. 2 (1): 52–5. doi:10.1038/sj.gene.6363722. PMID 11294570.
Kaminker PG, Kim SH, Taylor RD, et al. (2001). "TANK2, a new TRF1-associated poly(ADP-ribose) polymerase, causes rapid induction of cell death upon overexpression.". J. Biol. Chem. 276 (38): 35891–9. doi:10.1074/jbc.M105968200. PMID 11454873.
Cook BD, Dynek JN, Chang W, et al. (2002). "Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres.". Mol. Cell. Biol. 22 (1): 332–42. doi:10.1128/MCB.22.1.332-342.2002. PMC 134233. PMID 11739745. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=134233.
Sbodio JI, Lodish HF, Chi NW (2002). "Tankyrase-2 oligomerizes with tankyrase-1 and binds to both TRF1 (telomere-repeat-binding factor 1) and IRAP (insulin-responsive aminopeptidase).". Biochem. J. 361 (Pt 3): 451–9. doi:10.1042/0264-6021:3610451. PMC 1222327. PMID 11802774. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1222327.
Seimiya H, Smith S (2002). "The telomeric poly(ADP-ribose) polymerase, tankyrase 1, contains multiple binding sites for telomeric repeat binding factor 1 (TRF1) and a novel acceptor, 182-kDa tankyrase-binding protein (TAB182).". J. Biol. Chem. 277 (16): 14116–26. doi:10.1074/jbc.M112266200. PMID 11854288.
Sbodio JI, Chi NW (2002). "Identification of a tankyrase-binding motif shared by IRAP, TAB182, and human TRF1 but not mouse TRF1. NuMA contains this RXXPDG motif and is a novel tankyrase partner.". J. Biol. Chem. 277 (35): 31887–92. doi:10.1074/jbc.M203916200. PMID 12080061.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
Deng Z, Atanasiu C, Zhao K, et al. (2005). "Inhibition of Epstein-Barr virus OriP function by tankyrase, a telomere-associated poly-ADP ribose polymerase that binds and modifies EBNA1.". J. Virol. 79 (8): 4640–50. doi:10.1128/JVI.79.8.4640-4650.2005. PMC 1069541. PMID 15795250. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1069541.
Sidorova N, Zavalishina L, Kurchashova S, et al. (2006). "Immunohistochemical detection of tankyrase 2 in human breast tumors and normal renal tissue.". Cell Tissue Res. 323 (1): 137–45. doi:10.1007/s00441-005-0053-8. PMID 16151859.