TNIP1

TNFAIP3 interacting protein 1

Identifiers

TNIP1; ABIN-1; KIAA0113; NAF1; VAN

External IDs

OMIM: 607714 MGI: 1926194 HomoloGene: 31355 GeneCards: TNIP1 Gene

Gene Ontology
Molecular function	• protein binding
Cellular component	• intracellular • nucleus • cytoplasm
Biological process	• translation • defense response • glycoprotein biosynthetic process • negative regulation of viral genome replication
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000145901

ENSMUSG00000020400

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 5:
150.41 – 150.47 Mb

Chr 11:
54.72 – 54.78 Mb

PubMed search

TNFAIP3-interacting protein 1 is a protein that in humans is encoded by the TNIP1 gene.^[1]^[2]^[3]

Interactions

TNIP1 has been shown to interact with TNFAIP3^[4] and MAPK1.^[5]

References

^ Fukushi M, Dixon J, Kimura T, Tsurutani N, Dixon MJ, Yamamoto N (Feb 1999). "Identification and cloning of a novel cellular protein Naf1, Nef-associated factor 1, that increases cell surface CD4 expression". FEBS Lett 442 (1): 83–8. doi:10.1016/S0014-5793(98)01631-7. PMID 9923610.
^ Gupta K, Ott D, Hope TJ, Siliciano RF, Boeke JD (Jan 2001). "A Human Nuclear Shuttling Protein That Interacts with Human Immunodeficiency Virus Type 1 Matrix Is Packaged into Virions". J Virol 74 (24): 11811–24. doi:10.1128/JVI.74.24.11811-11824.2000. PMC 112464. PMID 11090181. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=112464.
^ "Entrez Gene: TNIP1 TNFAIP3 interacting protein 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10318.
^ Heyninck, K; De Valck D, Vanden Berghe W, Van Criekinge W, Contreras R, Fiers W, Haegeman G, Beyaert R (Jun. 1999). "The Zinc Finger Protein A20 Inhibits TNF-induced NF-κB–dependent Gene Expression by Interfering with an RIP- or TRAF2-mediated Transactivation Signal and Directly Binds to a Novel NF-κB–inhibiting Protein ABIN". J. Cell Biol. (UNITED STATES) 145 (7): 1471–82. doi:10.1083/jcb.145.7.1471. ISSN 0021-9525. PMC 2133159. PMID 10385526. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2133159.
^ Zhang, Shengliang; Fukushi Masaya, Hashimoto Shinichi, Gao Chongfeng, Huang Lin, Fukuyo Yayoi, Nakajima Takuma, Amagasa Teruo, Enomoto Shoji, Koike Katsuro, Miura Osamu, Yamamoto Naoki, Tsuchida Nobuo (Sep. 2002). "A new ERK2 binding protein, Naf1, attenuates the EGF/ERK2 nuclear signaling". Biochem. Biophys. Res. Commun. (United States) 297 (1): 17–23. doi:10.1016/S0006-291X(02)02086-7. ISSN 0006-291X. PMID 12220502.

Further reading

Nakajima D, Okazaki N, Yamakawa H et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
Nagase T, Miyajima N, Tanaka A et al. (1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (1): 37–43. doi:10.1093/dnares/2.1.37. PMID 7788527.
Loftus SK, Dixon J, Koprivnikar K et al. (1996). "Transcriptional map of the Treacher Collins candidate gene region". Genome Res. 6 (1): 26–34. doi:10.1101/gr.6.1.26. PMID 8681136.
Jäkel S, Görlich D (1998). "Importin beta, transportin, RanBP5 and RanBP7 mediate nuclear import of ribosomal proteins in mammalian cells". EMBO J. 17 (15): 4491–502. doi:10.1093/emboj/17.15.4491. PMC 1170780. PMID 9687515. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1170780.
Heyninck K, De Valck D, Vanden Berghe W et al. (1999). "The Zinc Finger Protein A20 Inhibits TNF-induced NF-κB–dependent Gene Expression by Interfering with an RIP- or TRAF2-mediated Transactivation Signal and Directly Binds to a Novel NF-κB–inhibiting Protein ABIN". J. Cell Biol. 145 (7): 1471–82. doi:10.1083/jcb.145.7.1471. PMC 2133159. PMID 10385526. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2133159.
Zhang S, Fukushi M, Hashimoto S et al. (2002). "A new ERK2 binding protein, Naf1, attenuates the EGF/ERK2 nuclear signaling". Biochem. Biophys. Res. Commun. 297 (1): 17–23. doi:10.1016/S0006-291X(02)02086-7. PMID 12220502.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Leonard D, Ajuh P, Lamond AI, Legerski RJ (2003). "hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing". Biochem. Biophys. Res. Commun. 308 (4): 793–801. doi:10.1016/S0006-291X(03)01486-4. PMID 12927788.
Gallagher J, Howlin J, McCarthy C et al. (2003). "Identification of Naf1/ABIN-1 among TNF-alpha-induced expressed genes in human synoviocytes using oligonucleotide microarrays". FEBS Lett. 551 (1–3): 8–12. doi:10.1016/S0014-5793(03)00823-8. PMID 12965196.
Favre M, Butticaz C, Stevenson B et al. (2003). "High frequency of alternative splicing of human genes participating in the HIV-1 life cycle: a model using TSG101, betaTrCP, PPIA, INI1, NAF1, and PML". J. Acquir. Immune Defic. Syndr. 34 (2): 127–33. doi:10.1097/00126334-200310010-00002. PMID 14526201.
Bouwmeester T, Bauch A, Ruffner H et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
Colland F, Jacq X, Trouplin V et al. (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=442148.
Suzuki Y, Yamashita R, Shirota M et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=515316.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Kimura K, Wakamatsu A, Suzuki Y et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1356129.
Hoareau-Aveilla C, Bonoli M, Caizergues-Ferrer M, Henry Y (2006). "hNaf1 is required for accumulation of human box H/ACA snoRNPs, scaRNPs, and telomerase". RNA 12 (5): 832–40. doi:10.1261/rna.2344106. PMC 1440901. PMID 16601202. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1440901.