GenVec

GenVec, Inc.
Type Public company
Traded as NASDAQ: GNVC
Industry Pharmaceuticals
Headquarters Gaithersburg, Maryland, United States
Key people Paul H. Fischer, President and CEO
Douglas J. Swirsky, Senior Vice President and Chief Financial Officer
Products TNFeradeTM Phase III
Revenue $13.9 million (2009)
Net income $18.4 million (2009)
Employees 85
Website www.genvec.com

GenVec, Inc. is a biopharmaceutical company developing pharmaceuticals and vaccines based on novel biotechnology such as targeted delivery systems. The company has a number of drugs currently in various phases of clinical trials. Its lead product candidate is TNFerade, being developed for the treatment of solid tumors. The company has been contracted by the United States Department of Homeland Security to develop a vaccine for foot-and-mouth disease.[1]

TNFerade

TNFerade (the Company's lead product candidate) failed a phase III trial for pancreatic cancer. There was an 8% reduction in risk of death but it was not statistically significant.[2] TNFerade is “an adenovector, or DNA carrier, which contains the gene for tumor necrosis factor-alpha (TNFα), an immune system protein, for direct injection into tumors”.[2]

References

  1. ^ Sinha, Vandana (2008-03-14). "GenVec reports narrowed losses" (in English). Washington Business Journal (Advance Publications). 
  2. ^ a b "Why GenVec’s TNFerade adenovector did not work in the Phase III pancreatic cancer trial?". 14 Apr 2010. http://oncolyticvirus.wordpress.com/2010/04/14/why-genvec%E2%80%99s-tnferade-adenovector-did-not-work-in-the-phase-iii-pancreatic-cancer-trial/. 
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