TNFSF12

Tumor necrosis factor (ligand) superfamily, member 12

Identifiers

TNFSF12; APO3L; DR3LG; MGC129581; MGC20669; TWEAK

External IDs

OMIM: 602695 MGI: 1196259 HomoloGene: 7979 GeneCards: TNFSF12 Gene

Gene Ontology
Molecular function	• receptor binding • cytokine activity • tumor necrosis factor receptor binding • protein binding
Cellular component	• extracellular region • extracellular space • plasma membrane • integral to plasma membrane • perinuclear region of cytoplasm
Biological process	• positive regulation of endothelial cell proliferation • apoptosis • induction of apoptosis • immune response • signal transduction • multicellular organismal development • cell differentiation • endothelial cell migration • positive regulation of angiogenesis
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

n/a

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 17:
7.45 – 7.46 Mb

Chr 11:
69.5 – 69.51 Mb

PubMed search

[1]

[2]

Tumor necrosis factor ligand superfamily member 12 is a protein that in humans is encoded by the TNFSF12 gene.^[1]^[2]^[3]

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis.^[3]

References

^ Chicheportiche Y, Bourdon PR, Xu H, Hsu YM, Scott H, Hession C, Garcia I, Browning JL (Jan 1998). "TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis". J Biol Chem 272 (51): 32401–10. doi:10.1074/jbc.272.51.32401. PMID 9405449.
^ Marsters SA, Sheridan JP, Pitti RM, Brush J, Goddard A, Ashkenazi A (Aug 1998). "Identification of a ligand for the death-domain-containing receptor Apo3". Curr Biol 8 (9): 525–8. doi:10.1016/S0960-9822(98)70204-0. PMID 9560343.
^ ^a ^b "Entrez Gene: TNFSF12 tumor necrosis factor (ligand) superfamily, member 12". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8742.

Wiley SR, Winkles JA (2004). "TWEAK, a member of the TNF superfamily, is a multifunctional cytokine that binds the TweakR/Fn14 receptor". Cytokine Growth Factor Rev. 14 (3–4): 241–9. doi:10.1016/S1359-6101(03)00019-4. PMID 12787562.
Campbell S, Michaelson J, Burkly L, Putterman C (2006). "The role of TWEAK/Fn14 in the pathogenesis of inflammation and systemic autoimmunity". Front. Biosci. 9: 2273–84. doi:10.2741/1395. PMID 15353286.
Lynch CN, Wang YC, Lund JK, et al. (1999). "TWEAK induces angiogenesis and proliferation of endothelial cells". J. Biol. Chem. 274 (13): 8455–9. doi:10.1074/jbc.274.13.8455. PMID 10085077.
Kaplan MJ, Ray D, Mo RR, et al. (2000). "TRAIL (Apo2 ligand) and TWEAK (Apo3 ligand) mediate CD4+ T cell killing of antigen-presenting macrophages". J. Immunol. 164 (6): 2897–904. PMID 10706675.
Kaptein A, Jansen M, Dilaver G, et al. (2000). "Studies on the interaction between TWEAK and the death receptor WSL-1/TRAMP (DR3)". FEBS Lett. 485 (2–3): 135–41. doi:10.1016/S0014-5793(00)02219-5. PMID 11094155.
Wiley SR, Cassiano L, Lofton T, et al. (2001). "A novel TNF receptor family member binds TWEAK and is implicated in angiogenesis". Immunity 15 (5): 837–46. doi:10.1016/S1074-7613(01)00232-1. PMID 11728344.
Nakayama M, Ishidoh K, Kayagaki N, et al. (2002). "Multiple pathways of TWEAK-induced cell death". J. Immunol. 168 (2): 734–43. PMID 11777967.
Jakubowski A, Browning B, Lukashev M, et al. (2002). "Dual role for TWEAK in angiogenic regulation". J. Cell. Sci. 115 (Pt 2): 267–74. PMID 11839778.
Kaplan MJ, Lewis EE, Shelden EA, et al. (2003). "The apoptotic ligands TRAIL, TWEAK, and Fas ligand mediate monocyte death induced by autologous lupus T cells". J. Immunol. 169 (10): 6020–9. PMID 12421989.
Harada N, Nakayama M, Nakano H, et al. (2003). "Pro-inflammatory effect of TWEAK/Fn14 interaction on human umbilical vein endothelial cells". Biochem. Biophys. Res. Commun. 299 (3): 488–93. doi:10.1016/S0006-291X(02)02670-0. PMID 12445828.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Nakayama M, Ishidoh K, Kojima Y, et al. (2003). "Fibroblast growth factor-inducible 14 mediates multiple pathways of TWEAK-induced cell death". J. Immunol. 170 (1): 341–8. PMID 12496418.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=403697.
Tian XL, Kadaba R, You SA, et al. (2004). "Identification of an angiogenic factor that when mutated causes susceptibility to Klippel-Trenaunay syndrome". Nature 427 (6975): 640–5. doi:10.1038/nature02320. PMC 1618873. PMID 14961121. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1618873.
Kim SH, Kang YJ, Kim WJ, et al. (2004). "TWEAK can induce pro-inflammatory cytokines and matrix metalloproteinase-9 in macrophages". Circ. J. 68 (4): 396–9. doi:10.1253/circj.68.396. PMID 15056843.
Jin L, Nakao A, Nakayama M, et al. (2004). "Induction of RANTES by TWEAK/Fn14 interaction in human keratinocytes". J. Invest. Dermatol. 122 (5): 1175–9. doi:10.1111/j.0022-202X.2004.22419.x. PMID 15140220.

TNFSF12

References

Further reading