TLK2
Serine/threonine-protein kinase tousled-like 2 is an enzyme that in humans is encoded by the TLK2 gene.[1][2][3]
The Tousled-like kinases, first described in Arabidopsis, are nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly.[supplied by OMIM][3]
Interactions
TLK2 has been shown to interact with TLK1,[2] ASF1B[4][5] and ASF1A.[5]
References
- ^ Yamakawa A, Kameoka Y, Hashimoto K, Yoshitake Y, Nishikawa K, Tanihara K, Date T (Jan 1998). "cDNA cloning and chromosomal mapping of genes encoding novel protein kinases termed PKU-alpha and PKU-beta, which have nuclear localization signal". Gene 202 (1–2): 193–201. doi:10.1016/S0378-1119(97)00495-2. PMID 9427565.
- ^ a b Sillje HH, Takahashi K, Tanaka K, Van Houwe G, Nigg EA (Dec 1999). "Mammalian homologues of the plant Tousled gene code for cell-cycle-regulated kinases with maximal activities linked to ongoing DNA replication". EMBO J 18 (20): 5691–702. doi:10.1093/emboj/18.20.5691. PMC 1171636. PMID 10523312. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1171636.
- ^ a b "Entrez Gene: TLK2 tousled-like kinase 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11011.
- ^ Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847948.
- ^ a b Silljé, H H; Nigg E A (Jul. 2001). "Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases". Curr. Biol. (England) 11 (13): 1068–73. doi:10.1016/S0960-9822(01)00298-6. ISSN 0960-9822. PMID 11470414.
Further reading
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Zhang S, Xing H, Muslin AJ (1999). "Nuclear localization of protein kinase U-alpha is regulated by 14-3-3". J. Biol. Chem. 274 (35): 24865–72. doi:10.1074/jbc.274.35.24865. PMID 10455159.
- Silljé HH, Nigg EA (2001). "Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases". Curr. Biol. 11 (13): 1068–73. doi:10.1016/S0960-9822(01)00298-6. PMID 11470414.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Groth A, Lukas J, Nigg EA, et al. (2003). "Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint". EMBO J. 22 (7): 1676–87. doi:10.1093/emboj/cdg151. PMC 152895. PMID 12660173. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=152895.
- Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=514446.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847948.