TLK1
Serine/threonine-protein kinase tousled-like 1 is an enzyme that in humans is encoded by the TLK1 gene.[1][2][3]
The Tousled-like kinases, first described in Arabadopsis, are nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly.[supplied by OMIM][3]
Interactions
TLK1 has been shown to interact with ASF1B,[4][5] ASF1A[4][6] and TLK2.[7]
References
- ^ Yamakawa A, Kameoka Y, Hashimoto K, Yoshitake Y, Nishikawa K, Tanihara K, Date T (Jan 1998). "cDNA cloning and chromosomal mapping of genes encoding novel protein kinases termed PKU-alpha and PKU-beta, which have nuclear localization signal". Gene 202 (1–2): 193–201. doi:10.1016/S0378-1119(97)00495-2. PMID 9427565.
- ^ Groth A, Lukas J, Nigg EA, Sillje HH, Wernstedt C, Bartek J, Hansen K (Mar 2003). "Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint". EMBO J 22 (7): 1676–87. doi:10.1093/emboj/cdg151. PMC 152895. PMID 12660173. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=152895.
- ^ a b "Entrez Gene: TLK1 tousled-like kinase 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9874.
- ^ a b Silljé, H H; Nigg E A (Jul. 2001). "Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases". Curr. Biol. (England) 11 (13): 1068–73. doi:10.1016/S0960-9822(01)00298-6. ISSN 0960-9822. PMID 11470414.
- ^ Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847948.
- ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct. 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- ^ Silljé, H H; Takahashi K, Tanaka K, Van Houwe G, Nigg E A (Oct. 1999). "Mammalian homologues of the plant Tousled gene code for cell-cycle-regulated kinases with maximal activities linked to ongoing DNA replication". EMBO J. (ENGLAND) 18 (20): 5691–702. doi:10.1093/emboj/18.20.5691. ISSN 0261-4189. PMC 1171636. PMID 10523312. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1171636.
Further reading
- Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
- Schultz SJ, Nigg EA (1994). "Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans". Cell Growth Differ. 4 (10): 821–30. PMID 8274451.
- Nagase T, Seki N, Tanaka A, et al. (1996). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (4): 167–74, 199–210. doi:10.1093/dnares/2.4.167. PMID 8590280.
- Silljé HH, Takahashi K, Tanaka K, et al. (1999). "Mammalian homologues of the plant Tousled gene code for cell-cycle-regulated kinases with maximal activities linked to ongoing DNA replication". EMBO J. 18 (20): 5691–702. doi:10.1093/emboj/18.20.5691. PMC 1171636. PMID 10523312. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1171636.
- Cabaniols JP, Ravichandran V, Roche PA (2000). "Phosphorylation of SNAP-23 by the novel kinase SNAK regulates t-SNARE complex assembly". Mol. Biol. Cell 10 (12): 4033–41. PMC 25741. PMID 10588641. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=25741.
- Li Y, DeFatta R, Anthony C, et al. (2001). "A translationally regulated Tousled kinase phosphorylates histone H3 and confers radioresistance when overexpressed". Oncogene 20 (6): 726–38. doi:10.1038/sj.onc.1204147. PMID 11314006.
- Silljé HH, Nigg EA (2001). "Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases". Curr. Biol. 11 (13): 1068–73. doi:10.1016/S0960-9822(01)00298-6. PMID 11470414.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Krause DR, Jonnalagadda JC, Gatei MH, et al. (2003). "Suppression of Tousled-like kinase activity after DNA damage or replication block requires ATM, NBS1 and Chk1". Oncogene 22 (38): 5927–37. doi:10.1038/sj.onc.1206691. PMID 12955071.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Norton KS, McClusky D, Sen S, et al. (2004). "TLK1B is elevated with eIF4E overexpression in breast cancer". J. Surg. Res. 116 (1): 98–103. doi:10.1016/j.jss.2003.08.001. PMID 14732354.
- Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=514446.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Kodym R, Henöckl C, Fürweger C (2005). "Identification of the human DEAD-box protein p68 as a substrate of Tlk1". Biochem. Biophys. Res. Commun. 333 (2): 411–7. doi:10.1016/j.bbrc.2005.05.136. PMID 15950181.
- Sunavala-Dossabhoy G, Balakrishnan SK, Sen S, et al. (2006). "The radioresistance kinase TLK1B protects the cells by promoting repair of double strand breaks". BMC Mol. Biol. 6: 19. doi:10.1186/1471-2199-6-19. PMC 1242231. PMID 16156902. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1242231.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Sen SP, De Benedetti A (2006). "TLK1B promotes repair of UV-damaged DNA through chromatin remodeling by Asf1". BMC Mol. Biol. 7: 37. doi:10.1186/1471-2199-7-37. PMC 1626478. PMID 17054786. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1626478.