TLK1

Tousled-like kinase 1
Identifiers
Symbols TLK1; KIAA0137; PKU-beta
External IDs OMIM608438 MGI2441683 HomoloGene8185 GeneCards: TLK1 Gene
EC number 2.7.11.1
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 9874 228012
Ensembl ENSG00000198586 ENSMUSG00000041997
UniProt Q9UKI8 A0PJK0
RefSeq (mRNA) NM_001136554.1 NM_172664.3
RefSeq (protein) NP_001130026.1 NP_766252.2
Location (UCSC) Chr 2:
171.85 – 172.09 Mb
Chr 2:
70.55 – 70.66 Mb
PubMed search [1] [2]

Serine/threonine-protein kinase tousled-like 1 is an enzyme that in humans is encoded by the TLK1 gene.[1][2][3]

The Tousled-like kinases, first described in Arabadopsis, are nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly.[supplied by OMIM][3]

Interactions

TLK1 has been shown to interact with ASF1B,[4][5] ASF1A[4][6] and TLK2.[7]

References

  1. ^ Yamakawa A, Kameoka Y, Hashimoto K, Yoshitake Y, Nishikawa K, Tanihara K, Date T (Jan 1998). "cDNA cloning and chromosomal mapping of genes encoding novel protein kinases termed PKU-alpha and PKU-beta, which have nuclear localization signal". Gene 202 (1–2): 193–201. doi:10.1016/S0378-1119(97)00495-2. PMID 9427565. 
  2. ^ Groth A, Lukas J, Nigg EA, Sillje HH, Wernstedt C, Bartek J, Hansen K (Mar 2003). "Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint". EMBO J 22 (7): 1676–87. doi:10.1093/emboj/cdg151. PMC 152895. PMID 12660173. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=152895. 
  3. ^ a b "Entrez Gene: TLK1 tousled-like kinase 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9874. 
  4. ^ a b Silljé, H H; Nigg E A (Jul. 2001). "Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases". Curr. Biol. (England) 11 (13): 1068–73. doi:10.1016/S0960-9822(01)00298-6. ISSN 0960-9822. PMID 11470414. 
  5. ^ Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847948. 
  6. ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct. 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  7. ^ Silljé, H H; Takahashi K, Tanaka K, Van Houwe G, Nigg E A (Oct. 1999). "Mammalian homologues of the plant Tousled gene code for cell-cycle-regulated kinases with maximal activities linked to ongoing DNA replication". EMBO J. (ENGLAND) 18 (20): 5691–702. doi:10.1093/emboj/18.20.5691. ISSN 0261-4189. PMC 1171636. PMID 10523312. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1171636. 

Further reading