| TIA1 cytotoxic granule-associated RNA binding protein | |
|---|---|
| Identifiers | |
| Symbol | TIA1 |
| Entrez | 7072 |
| HUGO | 11802 |
| OMIM | 603518 |
| RefSeq | NM_022173 |
| UniProt | P31483 |
| Other data | |
| Locus | Chr. 2 p13 |
TIA1 is a 3'UTR mRNA binding protein and can bind the 5'TOPsequence of 5'TOP mRNAs. It is associated with programmed cell death (apoptosis) and regulates alternative splicing of the gene encoding the Fas receptor, an apoptosis-promoting protein[1].