THBS2

Thrombospondin 2

PDB rendering based on 1yo8.

Available structures
PDB	1YO8, 2RHP

Identifiers

Symbols

THBS2; TSP2

External IDs

OMIM: 188061 MGI: 98738 HomoloGene: 2438 GeneCards: THBS2 Gene

Gene Ontology
Molecular function	• structural molecule activity • calcium ion binding • protein binding • heparin binding
Cellular component	• extracellular region
Biological process	• cell adhesion
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 6:
169.62 – 169.65 Mb

Chr 17:
14.8 – 14.83 Mb

PubMed search

[1]

[2]

Thrombospondin-2 is a protein that in humans is encoded by the THBS2 gene.^[1]^[2]

The protein encoded by this gene belongs to the thrombospondin family. It is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein has been shown to function as a potent inhibitor of tumor growth and angiogenesis. Studies of the mouse counterpart suggest that this protein may modulate the cell surface properties of mesenchymal cells and be involved in cell adhesion and migration.^[2]

Interactions

THBS2 has been shown to interact with MMP2.^[3]

References

^ Hirose Y, Chiba K, Karasugi T, Nakajima M, Kawaguchi Y, Mikami Y, Furuichi T, Mio F, Miyake A, Miyamoto T, Ozaki K, Takahashi A, Mizuta H, Kubo T, Kimura T, Tanaka T, Toyama Y, Ikegawa S (May 2008). "A functional polymorphism in THBS2 that affects alternative splicing and MMP binding is associated with lumbar-disc herniation". Am J Hum Genet 82 (5): 1122–9. doi:10.1016/j.ajhg.2008.03.013. PMC 2427305. PMID 18455130. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2427305.
^ ^a ^b "Entrez Gene: THBS2 thrombospondin 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7058.
^ Bein, K; Simons M (Oct. 2000). "Thrombospondin type 1 repeats interact with matrix metalloproteinase 2. Regulation of metalloproteinase activity". J. Biol. Chem. (UNITED STATES) 275 (41): 32167–73. doi:10.1074/jbc.M003834200. ISSN 0021-9258. PMID 10900205.

Bornstein P, Kyriakides TR, Yang Z, et al. (2001). "Thrombospondin 2 modulates collagen fibrillogenesis and angiogenesis.". J. Investig. Dermatol. Symp. Proc. 5 (1): 61–6. doi:10.1046/j.1087-0024.2000.00005.x. PMID 11147677.
O'Rourke KM, Laherty CD, Dixit VM (1993). "Thrombospondin 1 and thrombospondin 2 are expressed as both homo- and heterotrimers.". J. Biol. Chem. 267 (35): 24921–4. PMID 1459996.
LaBell TL, Milewicz DJ, Disteche CM, Byers PH (1992). "Thrombospondin II: partial cDNA sequence, chromosome location, and expression of a second member of the thrombospondin gene family in humans.". Genomics 12 (3): 421–9. doi:10.1016/0888-7543(92)90430-Z. PMID 1559694.
LaBell TL, Byers PH (1993). "Sequence and characterization of the complete human thrombospondin 2 cDNA: potential regulatory role for the 3' untranslated region.". Genomics 17 (1): 225–9. doi:10.1006/geno.1993.1308. PMID 8406456.
Adolph KW, Liska DJ, Bornstein P (1997). "Analysis of the promoter and transcription start sites of the human thrombospondin 2 gene (THBS2).". Gene 193 (1): 5–11. doi:10.1016/S0378-1119(97)00070-X. PMID 9249061.
Kyriakides TR, Zhu YH, Smith LT, et al. (1998). "Mice that lack thrombospondin 2 display connective tissue abnormalities that are associated with disordered collagen fibrillogenesis, an increased vascular density, and a bleeding diathesis.". J. Cell Biol. 140 (2): 419–30. doi:10.1083/jcb.140.2.419. PMC 2132586. PMID 9442117. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2132586.
Adolph KW (1999). "Relative abundance of thrombospondin 2 and thrombospondin 3 mRNAs in human tissues.". Biochem. Biophys. Res. Commun. 258 (3): 792–6. doi:10.1006/bbrc.1999.0710. PMID 10329465.
Carron JA, Bowler WB, Wagstaff SC, Gallagher JA (1999). "Expression of members of the thrombospondin family by human skeletal tissues and cultured cells.". Biochem. Biophys. Res. Commun. 263 (2): 389–91. doi:10.1006/bbrc.1999.1380. PMID 10491303.
Bein K, Simons M (2000). "Thrombospondin type 1 repeats interact with matrix metalloproteinase 2. Regulation of metalloproteinase activity.". J. Biol. Chem. 275 (41): 32167–73. doi:10.1074/jbc.M003834200. PMID 10900205.
Hawighorst T, Velasco P, Streit M, et al. (2001). "Thrombospondin-2 plays a protective role in multistep carcinogenesis: a novel host anti-tumor defense mechanism.". EMBO J. 20 (11): 2631–40. doi:10.1093/emboj/20.11.2631. PMC 125494. PMID 11387198. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=125494.
Misenheimer TM, Hahr AJ, Harms AC, et al. (2002). "Disulfide connectivity of recombinant C-terminal region of human thrombospondin 2.". J. Biol. Chem. 276 (49): 45882–7. doi:10.1074/jbc.M104218200. PMID 11590138.
Armstrong DJ, Hiscott P, Batterbury M, Kaye S (2002). "Corneal stromal cells (keratocytes) express thrombospondins 2 and 3 in wound repair phenotype.". Int. J. Biochem. Cell Biol. 34 (6): 588–93. doi:10.1016/S1357-2725(01)00157-1. PMID 11943589.
Li Z, Calzada MJ, Sipes JM, et al. (2002). "Interactions of thrombospondins with alpha4beta1 integrin and CD47 differentially modulate T cell behavior.". J. Cell Biol. 157 (3): 509–19. doi:10.1083/jcb.200109098. PMC 2173289. PMID 11980922. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2173289.
Armstrong LC, Björkblom B, Hankenson KD, et al. (2002). "Thrombospondin 2 inhibits microvascular endothelial cell proliferation by a caspase-independent mechanism.". Mol. Biol. Cell 13 (6): 1893–905. doi:10.1091/mbc.E01-09-0066.. PMC 117612. PMID 12058057. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=117612.
Hatakeyama H, Nishizawa M, Nakagawa A, et al. (2003). "Thrombospondin expression in aldosterone-producing adenomas.". Hypertens. Res. 25 (4): 523–7. doi:10.1291/hypres.25.523. PMID 12358136.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Boekholdt SM, Trip MD, Peters RJ, et al. (2002). "Thrombospondin-2 polymorphism is associated with a reduced risk of premature myocardial infarction.". Arterioscler. Thromb. Vasc. Biol. 22 (12): e24–7. doi:10.1161/01.ATV.0000046235.22451.66. PMID 12482844.
Kyriakides TR, Rojnuckarin P, Reidy MA, et al. (2003). "Megakaryocytes require thrombospondin-2 for normal platelet formation and function.". Blood 101 (10): 3915–23. doi:10.1182/blood.V101.10.3915. PMID 12732502.
Kishi M, Nakamura M, Nishimine M, et al. (2003). "Loss of heterozygosity on chromosome 6q correlates with decreased thrombospondin-2 expression in human salivary gland carcinomas.". Cancer Sci. 94 (6): 530–5. doi:10.1111/j.1349-7006.2003.tb01478.x. PMID 12824879.

PDB gallery

1yo8: Strucuture of the C-terminal domain of human thrombospondin-2

THBS2

Interactions

References

Further reading