TGM4

For the video game, see Tetris: The Grand Master.

Transglutaminase 4 (prostate)

Identifiers

Symbols

TGM4; FLJ26776; TGP; hTGP

External IDs

OMIM: 600585 MGI: 3027002 HomoloGene: 20689 GeneCards: TGM4 Gene

EC number

2.3.2.13

Gene Ontology
Molecular function	• protein-glutamine gamma-glutamyltransferase activity • acyltransferase activity • transferase activity • metal ion binding
Cellular component	• cellular_component
Biological process	• peptide cross-linking • protein polyamination
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

n/a

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 3:
44.92 – 44.96 Mb

Chr 9:
122.94 – 122.98 Mb

PubMed search

[1]

[2]

Protein-glutamine gamma-glutamyltransferase 4 is an enzyme that in humans is encoded by the TGM4 gene.^[1]^[2]^[3]

References

^ Gentile V, Grant FJ, Porta R, Baldini A (Oct 1995). "Localization of the human prostate transglutaminase (type IV) gene (TGM4) to chromosome 3p21.33-p22 by fluorescence in situ hybridization". Genomics 27 (1): 219–20. doi:10.1006/geno.1995.1032. PMID 7665178.
^ Grant FJ, Taylor DA, Sheppard PO, Mathewes SL, Lint W, Vanaja E, Bishop PD, O'Hara PJ (Oct 1994). "Molecular cloning and characterization of a novel transglutaminase cDNA from a human prostate cDNA library". Biochem Biophys Res Commun 203 (2): 1117–23. doi:10.1006/bbrc.1994.2298. PMID 7916568.
^ "Entrez Gene: TGM4 transglutaminase 4 (prostate)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7047.

Davies G, Ablin RJ, Mason MD, Jiang WG (2007). "Expression of the prostate transglutaminase (TGase-4) in prostate cancer cells and its impact on the invasiveness of prostate cancer.". J. Exp. Ther. Oncol. 6 (3): 257–64. PMID 17552366.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1356129.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Dubbink HJ, de Waal L, van Haperen R, et al. (1998). "The human prostate-specific transglutaminase gene (TGM4): genomic organization, tissue-specific expression, and promoter characterization". Genomics 51 (3): 434–44. doi:10.1006/geno.1998.5393. PMID 9721214.
Dubbink HJ, Verkaik NS, Faber PW, et al. (1996). "Tissue specific and androgen-regulated expression of human prostate-specific transglutaminase". Biochem. J. 315 ( Pt 3) (Pt 3): 901–8. PMC 1217292. PMID 8645175. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1217292.
Amendola A, Lombardi G, Oliverio S, et al. (1994). "HIV-1 gp120-dependent induction of apoptosis in antigen-specific human T cell clones is characterized by 'tissue' transglutaminase expression and prevented by cyclosporin A". FEBS Lett. 339 (3): 258–64. doi:10.1016/0014-5793(94)80427-3. PMID 7906657.
Mariniello L, Esposito C, Di Pierro P, et al. (1993). "Human-immunodeficiency-virus transmembrane glycoprotein gp41 is an amino acceptor and donor substrate for transglutaminase in vitro". Eur. J. Biochem. 215 (1): 99–104. doi:10.1111/j.1432-1033.1993.tb18011.x. PMID 7688299.

TGM4

References

Further reading