Transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa) is a TGF beta receptor. TGFBR1 is its human gene.
The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS).[1]
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TGF beta receptor 1 has been shown to interact with Mothers against decapentaplegic homolog 7,[2][3][4][5][6][7] FKBP1A,[8][9] TGF beta 1,[10][11] Caveolin 1,[12] FNTA,[13] PPP2R2A,[14] TGF beta receptor 2,[12][15] Endoglin,[16][17] Heat shock protein 90kDa alpha (cytosolic), member A1[18] and STRAP.[7][19]
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