TFDP1

Transcription factor Dp-1

PDB rendering based on 2aze.

Available structures
PDB	2aze

Identifiers

Symbols

TFDP1; DP1; DRTF1; Dp-1

External IDs

OMIM: 189902 MGI: 101934 HomoloGene: 38276 GeneCards: TFDP1 Gene

Gene Ontology
Molecular function	• DNA binding • sequence-specific DNA binding transcription factor activity • transcription coactivator activity • transcription factor binding • protein domain specific binding
Cellular component	• nucleus • nucleoplasm • transcription factor complex
Biological process	• G1 phase of mitotic cell cycle • G1/S transition of mitotic cell cycle • mitotic cell cycle • transcription, DNA-dependent • regulation of transcription from RNA polymerase II promoter • cell proliferation
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 13:
114.24 – 114.3 Mb

Chr 8:
13.34 – 13.38 Mb

PubMed search

[1]

[2]

Transcription factor Dp-1 is a protein that in humans is encoded by the TFDP1 gene.^[1]^[2]^[3]

The E2F transcription factor family (see MIM 189971) regulates the expression of various cellular promoters, particularly those involved in the cell cycle. E2F factors bind to DNA as homodimers or heterodimers in association with dimerization partner DP1. TFDP1 may be the first example of a family of related transcription factors; see TFDP2 (MIM 602160).[supplied by OMIM]^[3]

Interactions

TFDP1 has been shown to interact with E2F1,^[4]^[5]^[6]^[7] E2F5^[8]^[4] and P53.^[9]

References

^ Girling R, Partridge JF, Bandara LR, Burden N, Totty NF, Hsuan JJ, La Thangue NB (Nov 1993). "A new component of the transcription factor DRTF1/E2F". Nature 365 (6445): 468. doi:10.1038/365468d0. PMID 8413592.
^ Zhang Y, Venkatraj VS, Fischer SG, Warburton D, Chellappan SP (Mar 1997). "Genomic cloning and chromosomal assignment of the E2F dimerization partner TFDP gene family". Genomics 39 (1): 95–8. doi:10.1006/geno.1996.4473. PMID 9027491.
^ ^a ^b "Entrez Gene: TFDP1 transcription factor Dp-1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7027.
^ ^a ^b Sardet, C; Vidal M, Cobrinik D, Geng Y, Onufryk C, Chen A, Weinberg R A (Mar. 1995). "E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 92 (6): 2403–7. doi:10.1073/pnas.92.6.2403. ISSN 0027-8424. PMC 42492. PMID 7892279. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=42492.
^ Suzuki, M; Okuyama S, Okamoto S, Shirasuna K, Nakajima T, Hachiya T, Nojima H, Sekiya S, Oda K (Aug. 1998). "A novel E2F binding protein with Myc-type HLH motif stimulates E2F-dependent transcription by forming a heterodimer". Oncogene (ENGLAND) 17 (7): 853–65. doi:10.1038/sj.onc.1202163. ISSN 0950-9232. PMID 9780002.
^ Wu, C L; Zukerberg L R, Ngwu C, Harlow E, Lees J A (May. 1995). "In vivo association of E2F and DP family proteins". Mol. Cell. Biol. (UNITED STATES) 15 (5): 2536–46. ISSN 0270-7306. PMC 230484. PMID 7739537. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=230484.
^ Helin, K; Wu C L, Fattaey A R, Lees J A, Dynlacht B D, Ngwu C, Harlow E (Oct. 1993). "Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation". Genes Dev. (UNITED STATES) 7 (10): 1850–61. doi:10.1101/gad.7.10.1850. ISSN 0890-9369. PMID 8405995.
^ Hijmans, E M; Voorhoeve P M, Beijersbergen R L, van 't Veer L J, Bernards R (Jun. 1995). "E2F-5, a new E2F family member that interacts with p130 in vivo". Mol. Cell. Biol. (UNITED STATES) 15 (6): 3082–9. ISSN 0270-7306. PMC 230539. PMID 7760804. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=230539.
^ Sørensen, T S; Girling R, Lee C W, Gannon J, Bandara L R, La Thangue N B (Oct. 1996). "Functional interaction between DP-1 and p53". Mol. Cell. Biol. (UNITED STATES) 16 (10): 5888–95. ISSN 0270-7306. PMC 231590. PMID 8816502. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=231590.

Wu CL, Zukerberg LR, Ngwu C, et al. (1995). "In vivo association of E2F and DP family proteins.". Mol. Cell. Biol. 15 (5): 2536–46. PMC 230484. PMID 7739537. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=230484.
Hijmans EM, Voorhoeve PM, Beijersbergen RL, et al. (1995). "E2F-5, a new E2F family member that interacts with p130 in vivo.". Mol. Cell. Biol. 15 (6): 3082–9. PMC 230539. PMID 7760804. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=230539.
Sardet C, Vidal M, Cobrinik D, et al. (1995). "E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle.". Proc. Natl. Acad. Sci. U.S.A. 92 (6): 2403–7. doi:10.1073/pnas.92.6.2403. PMC 42492. PMID 7892279. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=42492.
Ginsberg D, Vairo G, Chittenden T, et al. (1994). "E2F-4, a new member of the E2F transcription factor family, interacts with p107.". Genes Dev. 8 (22): 2665–79. doi:10.1101/gad.8.22.2665. PMID 7958924.
Beijersbergen RL, Kerkhoven RM, Zhu L, et al. (1994). "E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo.". Genes Dev. 8 (22): 2680–90. doi:10.1101/gad.8.22.2680. PMID 7958925.
Bandara LR, Lam EW, Sørensen TS, et al. (1994). "DP-1: a cell cycle-regulated and phosphorylated component of transcription factor DRTF1/E2F which is functionally important for recognition by pRb and the adenovirus E4 orf 6/7 protein.". EMBO J. 13 (13): 3104–14. PMC 395201. PMID 8039504. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=395201.
Helin K, Wu CL, Fattaey AR, et al. (1993). "Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation.". Genes Dev. 7 (10): 1850–61. doi:10.1101/gad.7.10.1850. PMID 8405995.
Rogers KT, Higgins PD, Milla MM, et al. (1996). "DP-2, a heterodimeric partner of E2F: identification and characterization of DP-2 proteins expressed in vivo.". Proc. Natl. Acad. Sci. U.S.A. 93 (15): 7594–9. doi:10.1073/pnas.93.15.7594. PMC 38791. PMID 8755520. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=38791.
Sørensen TS, Girling R, Lee CW, et al. (1996). "Functional interaction between DP-1 and p53.". Mol. Cell. Biol. 16 (10): 5888–95. PMC 231590. PMID 8816502. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=231590.
Vidal M, Braun P, Chen E, et al. (1996). "Genetic characterization of a mammalian protein-protein interaction domain by using a yeast reverse two-hybrid system.". Proc. Natl. Acad. Sci. U.S.A. 93 (19): 10321–6. doi:10.1073/pnas.93.19.10321. PMC 38382. PMID 8816798. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=38382.
Magae J, Wu CL, Illenye S, et al. (1997). "Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family members.". J. Cell. Sci.. 109 ( Pt 7): 1717–26. PMID 8832394.
Hofmann F, Livingston DM (1996). "Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit.". Genes Dev. 10 (7): 851–61. doi:10.1101/gad.10.7.851. PMID 8846921.
Trimarchi JM, Fairchild B, Verona R, et al. (1998). "E2F-6, a member of the E2F family that can behave as a transcriptional repressor.". Proc. Natl. Acad. Sci. U.S.A. 95 (6): 2850–5. doi:10.1073/pnas.95.6.2850. PMC 19658. PMID 9501179. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=19658.
Cartwright P, Müller H, Wagener C, et al. (1998). "E2F-6: a novel member of the E2F family is an inhibitor of E2F-dependent transcription.". Oncogene 17 (5): 611–23. doi:10.1038/sj.onc.1201975. PMID 9704927.
Timchenko NA, Wilde M, Darlington GJ (1999). "C/EBPalpha regulates formation of S-phase-specific E2F-p107 complexes in livers of newborn mice.". Mol. Cell. Biol. 19 (4): 2936–45. PMC 84088. PMID 10082561. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=84088.
Lam EW, Glassford J, van der Sman J, et al. (1999). "Modulation of E2F activity in primary mouse B cells following stimulation via surface IgM and CD40 receptors.". Eur. J. Immunol. 29 (10): 3380–9. doi:10.1002/(SICI)1521-4141(199910)29:10<3380::AID-IMMU3380>3.0.CO;2-C. PMID 10540350.
Sansal I, Dupont E, Toru D, et al. (2000). "NPDC-1, a regulator of neural cell proliferation and differentiation, interacts with E2F-1, reduces its binding to DNA and modulates its transcriptional activity.". Oncogene 19 (43): 5000–9. doi:10.1038/sj.onc.1203843. PMID 11042687.
Hsu SI, Yang CM, Sim KG, et al. (2001). "TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1.". EMBO J. 20 (9): 2273–85. doi:10.1093/emboj/20.9.2273. PMC 125435. PMID 11331592. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=125435.

PDB gallery

2aze: Structure of the Rb C-terminal domain bound to an E2F1-DP1 heterodimer

TFDP1

Interactions

References

Further reading